| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDKN2B | PHLDB1 | ENSP00000276925 | ENSP00000354498 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family | Pleckstrin homology like domain family B member 1 | 0.596 |
| CDKN2B | RTEL1 | ENSP00000276925 | ENSP00000353332 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.515 |
| CDKN2B | TERT | ENSP00000276925 | ENSP00000309572 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] | 0.583 |
| DCBLD1 | DCUN1D3 | ENSP00000296955 | ENSP00000319482 | Discoidin, CUB and LCCL domain containing 1 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | 0.607 |
| DCBLD1 | DPAGT1 | ENSP00000296955 | ENSP00000386597 | Discoidin, CUB and LCCL domain containing 1 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | 0.561 |
| DCBLD1 | LEPREL2 | ENSP00000296955 | ENSP00000478600 | Discoidin, CUB and LCCL domain containing 1 | Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it function [...] | 0.573 |
| DCBLD1 | PHLDB1 | ENSP00000296955 | ENSP00000354498 | Discoidin, CUB and LCCL domain containing 1 | Pleckstrin homology like domain family B member 1 | 0.586 |
| DCBLD1 | TSPAN31 | ENSP00000296955 | ENSP00000257910 | Discoidin, CUB and LCCL domain containing 1 | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.595 |
| DCBLD1 | ZCCHC14 | ENSP00000296955 | ENSP00000268616 | Discoidin, CUB and LCCL domain containing 1 | Zinc finger CCHC domain-containing protein 14; Sterile alpha motif domain containing | 0.607 |
| DCUN1D3 | DCBLD1 | ENSP00000319482 | ENSP00000296955 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | Discoidin, CUB and LCCL domain containing 1 | 0.607 |
| DCUN1D3 | DPAGT1 | ENSP00000319482 | ENSP00000386597 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | 0.553 |
| DCUN1D3 | LEPREL2 | ENSP00000319482 | ENSP00000478600 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it function [...] | 0.571 |
| DCUN1D3 | PHLDB1 | ENSP00000319482 | ENSP00000354498 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | Pleckstrin homology like domain family B member 1 | 0.580 |
| DCUN1D3 | TSPAN31 | ENSP00000319482 | ENSP00000257910 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.584 |
| DCUN1D3 | ZCCHC14 | ENSP00000319482 | ENSP00000268616 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | Zinc finger CCHC domain-containing protein 14; Sterile alpha motif domain containing | 0.608 |
| DPAGT1 | DCBLD1 | ENSP00000386597 | ENSP00000296955 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | Discoidin, CUB and LCCL domain containing 1 | 0.561 |
| DPAGT1 | DCUN1D3 | ENSP00000386597 | ENSP00000319482 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar | 0.553 |
| DPAGT1 | LEPREL2 | ENSP00000386597 | ENSP00000478600 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it function [...] | 0.570 |
| DPAGT1 | PHLDB1 | ENSP00000386597 | ENSP00000354498 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | Pleckstrin homology like domain family B member 1 | 0.571 |
| DPAGT1 | TSPAN31 | ENSP00000386597 | ENSP00000257910 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.574 |
