| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COL9A1 | DUSP27 | ENSP00000349790 | ENSP00000354483 | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.642 |
| COL9A1 | KLHL38 | ENSP00000349790 | ENSP00000321475 | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | Kelch-like protein 38; Kelch like family member 38; BTB domain containing | 0.631 |
| DUSP27 | COL9A1 | ENSP00000354483 | ENSP00000349790 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.642 |
| DUSP27 | ESPNL | ENSP00000354483 | ENSP00000339115 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | 0.736 |
| DUSP27 | GLRB | ENSP00000354483 | ENSP00000264428 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.652 |
| DUSP27 | GUCY1A2 | ENSP00000354483 | ENSP00000282249 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.646 |
| DUSP27 | KLHL38 | ENSP00000354483 | ENSP00000321475 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Kelch-like protein 38; Kelch like family member 38; BTB domain containing | 0.752 |
| DUSP27 | MRVI1 | ENSP00000354483 | ENSP00000412130 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | 0.692 |
| DUSP27 | RCE1 | ENSP00000354483 | ENSP00000309163 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 | 0.633 |
| DUSP27 | SCLY | ENSP00000354483 | ENSP00000254663 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family | 0.637 |
| DUSP27 | SLC36A1 | ENSP00000354483 | ENSP00000243389 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity); Solute carriers | 0.687 |
| DUSP27 | YIF1B | ENSP00000354483 | ENSP00000343435 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.740 |
| ESPNL | DUSP27 | ENSP00000339115 | ENSP00000354483 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.736 |
| ESPNL | GLRB | ENSP00000339115 | ENSP00000264428 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | 0.668 |
| ESPNL | GUCY1A2 | ENSP00000339115 | ENSP00000282249 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.583 |
| ESPNL | MRVI1 | ENSP00000339115 | ENSP00000412130 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | 0.651 |
| ESPNL | RCE1 | ENSP00000339115 | ENSP00000309163 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 | 0.585 |
| ESPNL | SCLY | ENSP00000339115 | ENSP00000254663 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family | 0.536 |
| ESPNL | SLC36A1 | ENSP00000339115 | ENSP00000243389 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; Ankyrin repeat domain containing | Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity); Solute carriers | 0.515 |
| GLRB | DUSP27 | ENSP00000264428 | ENSP00000354483 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.652 |
