• Version:
  • 11.0 [archived version]
STRINGSTRING
CCDC17 CCDC17 ZNF684 ZNF684 PLEKHJ1 PLEKHJ1 OCRL OCRL FAM109B FAM109B FAM109A FAM109A TRAFD1 TRAFD1 INPP5B INPP5B TMEM116 TMEM116 CUX2 CUX2 TSPEAR TSPEAR
"FAM109A" - Sesquipedalian-1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FAM109ASesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain containing (262 aa)    
Predicted Functional Partners:
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1; Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly; Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family (901 aa)
       
 
  0.995
INPP5B
Type II inositol 1,4,5-trisphosphate 5-phosphatase; Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events; Phosphoinositide phosphatases (913 aa)
       
 
  0.967
PLEKHJ1
Pleckstrin homology domain containing J1 (277 aa)
       
   
0.933
FAM109B
Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family (259 aa)
     
 
0.793
CUX2
Homeobox protein cut-like 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity); CUT class homeoboxes and pseudogenes (1486 aa)
           
  0.640
TSPEAR
Thrombospondin-type laminin G domain and EAR repeat-containing protein; May play a role in development or function of the auditory system; Deafness associated genes (669 aa)
           
  0.623
TMEM116
Transmembrane protein 116 (337 aa)
           
  0.576
ZNF684
Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type (378 aa)
           
  0.558
CCDC17
Coiled-coil domain containing 17 (622 aa)
           
  0.546
TRAFD1
TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) (582 aa)
           
  0.543
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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