• Version:
  • 11.0 [archived version]
STRINGSTRING
TAT TAT CEL CEL CPB1 CPB1 CTRB1 CTRB1 MMP3 MMP3 CPA1 CPA1 MMP10 MMP10 MMP9 MMP9 CPA2 CPA2 CTRB2 CTRB2 TCN1 TCN1
"CTRB1" - Chymotrypsinogen B1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
CTRB1Chymotrypsinogen B1; Belongs to the peptidase S1 family (263 aa)    
Predicted Functional Partners:
CPA1
Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family (419 aa)
     
 
  0.945
MMP9
Matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide; M10 matrix metallopeptidases (707 aa)
         
  0.922
MMP3
Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family (477 aa)
         
  0.917
TCN1
Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach; Belongs to the eukaryotic cobalamin transport proteins family (433 aa)
         
  0.900
MMP10
Stromelysin-2; Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase; Belongs to the peptidase M10A family (476 aa)
         
    0.900
CTRB2
Chymotrypsinogen B2; Belongs to the peptidase S1 family (263 aa)
   
 
0.848
CPB1
M14 carboxypeptidases; Belongs to the peptidase M14 family (417 aa)
     
 
  0.829
CEL
Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B carboxylesterase/lipase family (756 aa)
     
 
  0.761
CPA2
M14 carboxypeptidases (419 aa)
     
 
  0.753
TAT
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine (454 aa)
     
   
  0.753
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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