C11orf80 protein (human) - STRING database

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C11orf80

Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (572 aa)

Predicted Functional Partners:

OR4K14

0.726

OR4N5

0.712

TMEM132C

0.683

ZNF473

0.668

FAM122C

0.642

KLHL4

0.636

SPO11

0.622

CCDC85A

0.600

RCE1

0.574

PABPC5

0.572

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf80	CCDC85A	ENSP00000354227	ENSP00000384040	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.600
C11orf80	FAM122C	ENSP00000354227	ENSP00000359820	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Protein FAM122C; Family with sequence similarity 122C	0.642
C11orf80	KLHL4	ENSP00000354227	ENSP00000362206	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.636
C11orf80	OR4K14	ENSP00000354227	ENSP00000305011	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.726
C11orf80	OR4N5	ENSP00000354227	ENSP00000332110	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.712
C11orf80	PABPC5	ENSP00000354227	ENSP00000308012	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity); RNA binding motif containing	0.572
C11orf80	RCE1	ENSP00000354227	ENSP00000309163	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1	0.574
C11orf80	SPO11	ENSP00000354227	ENSP00000360310	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2	0.622
C11orf80	TMEM132C	ENSP00000354227	ENSP00000410852	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.683
C11orf80	ZNF473	ENSP00000354227	ENSP00000472808	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type	0.668
CCDC85A	C11orf80	ENSP00000384040	ENSP00000354227	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.600
CCDC85A	KLHL4	ENSP00000384040	ENSP00000362206	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.552
CCDC85A	OR4K14	ENSP00000384040	ENSP00000305011	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.609
CCDC85A	OR4N5	ENSP00000384040	ENSP00000332110	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.577
CCDC85A	PABPC5	ENSP00000384040	ENSP00000308012	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity); RNA binding motif containing	0.534
CCDC85A	TMEM132C	ENSP00000384040	ENSP00000410852	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.620
CCDC85A	ZNF473	ENSP00000384040	ENSP00000472808	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type	0.547
FAM122C	C11orf80	ENSP00000359820	ENSP00000354227	Protein FAM122C; Family with sequence similarity 122C	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.642
KLHL4	C11orf80	ENSP00000362206	ENSP00000354227	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.636
KLHL4	CCDC85A	ENSP00000362206	ENSP00000384040	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.552

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