MPC1 protein (human) - STRING database

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MPC1

Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family (109 aa)

Predicted Functional Partners:

MPC2

0.998

SRSF5

0.818

GLB1

0.641

PRR18

0.575

RPS6

0.575

ITGA5

0.551

SFT2D1

0.550

RPS6KA2

0.540

UQCRFS1

0.538

USB1

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLB1	MPC1	ENSP00000306920	ENSP00000354223	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	0.641
GLB1	SRSF5	ENSP00000306920	ENSP00000452123	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	Serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites; RNA binding motif containing	0.833
ITGA5	MPC1	ENSP00000293379	ENSP00000354223	Integrin alpha-5; Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5-ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5-ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1; CD molecules	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	0.551
MPC1	GLB1	ENSP00000354223	ENSP00000306920	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	0.641
MPC1	ITGA5	ENSP00000354223	ENSP00000293379	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Integrin alpha-5; Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5-ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5-ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1; CD molecules	0.551
MPC1	MPC2	ENSP00000354223	ENSP00000356820	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	0.998
MPC1	PRR18	ENSP00000354223	ENSP00000319590	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Proline-rich protein 18; Proline rich 18	0.575
MPC1	RPS6	ENSP00000354223	ENSP00000369757	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins	0.575
MPC1	RPS6KA2	ENSP00000354223	ENSP00000427015	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Ribosomal protein S6 kinase alpha-2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells; Mitogen-activated protein kinase-activated protein kinases	0.540
MPC1	SFT2D1	ENSP00000354223	ENSP00000354590	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex	0.550
MPC1	SRSF5	ENSP00000354223	ENSP00000452123	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites; RNA binding motif containing	0.818
MPC1	UQCRFS1	ENSP00000354223	ENSP00000306397	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Cytochrome b-c1 complex subunit Rieske, mitochondrial- Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity)	0.538
MPC1	USB1	ENSP00000354223	ENSP00000219281	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3’ end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3’ end-terminated with a 2’,3’-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family	0.532
MPC2	MPC1	ENSP00000356820	ENSP00000354223	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	0.998
MPC2	PRR18	ENSP00000356820	ENSP00000319590	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	Proline-rich protein 18; Proline rich 18	0.539
MPC2	UQCRFS1	ENSP00000356820	ENSP00000306397	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Cytochrome b-c1 complex subunit Rieske, mitochondrial- Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity)	0.546
PRR18	MPC1	ENSP00000319590	ENSP00000354223	Proline-rich protein 18; Proline rich 18	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	0.575
PRR18	MPC2	ENSP00000319590	ENSP00000356820	Proline-rich protein 18; Proline rich 18	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	0.539
PRR18	SFT2D1	ENSP00000319590	ENSP00000354590	Proline-rich protein 18; Proline rich 18	Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex	0.686
RPS6	MPC1	ENSP00000369757	ENSP00000354223	40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins	Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	0.575

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