| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD9 | DCPS | ENSP00000286918 | ENSP00000263579 | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3’->5’ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5’-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hy [...] | 0.538 |
| ANKRD9 | FAM110A | ENSP00000286918 | ENSP00000354163 | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | 0.787 |
| ANKRD9 | NRG2 | ENSP00000286918 | ENSP00000354910 | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor; Belongs to the neuregulin family | 0.505 |
| ANKRD9 | WFDC12 | ENSP00000286918 | ENSP00000361871 | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.473 |
| CSPP1 | FAM110A | ENSP00000262210 | ENSP00000354163 | Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | 0.930 |
| DCPS | ANKRD9 | ENSP00000263579 | ENSP00000286918 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3’->5’ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5’-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hy [...] | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | 0.538 |
| DCPS | FAM110A | ENSP00000263579 | ENSP00000354163 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3’->5’ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5’-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hy [...] | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | 0.551 |
| FAM110A | ANKRD9 | ENSP00000354163 | ENSP00000286918 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing | 0.787 |
| FAM110A | CSPP1 | ENSP00000354163 | ENSP00000262210 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization | 0.930 |
| FAM110A | DCPS | ENSP00000354163 | ENSP00000263579 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3’->5’ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5’-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hy [...] | 0.551 |
| FAM110A | IL17A | ENSP00000354163 | ENSP00000344192 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines; Belongs to the IL-17 family | 0.524 |
| FAM110A | IL4 | ENSP00000354163 | ENSP00000231449 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity); Interleukins | 0.522 |
| FAM110A | IL9 | ENSP00000354163 | ENSP00000274520 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Interleukin-9; Supports IL-2 independent and IL-4 independent growth of helper T-cells; Interleukins | 0.626 |
| FAM110A | IRF4 | ENSP00000354163 | ENSP00000370343 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Interferon regulatory factor 4; Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5’-TGAnTCA/GAAA-3’), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and [...] | 0.503 |
| FAM110A | NRG2 | ENSP00000354163 | ENSP00000354910 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor; Belongs to the neuregulin family | 0.530 |
| FAM110A | TCP10L | ENSP00000354163 | ENSP00000300258 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | T-complex protein 10A homolog 2; May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells | 0.539 |
| FAM110A | WFDC12 | ENSP00000354163 | ENSP00000361871 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.556 |
| IL17A | FAM110A | ENSP00000344192 | ENSP00000354163 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines; Belongs to the IL-17 family | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family | 0.524 |
| IL17A | IL4 | ENSP00000344192 | ENSP00000231449 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines; Belongs to the IL-17 family | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity); Interleukins | 0.951 |
| IL17A | IL9 | ENSP00000344192 | ENSP00000274520 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines; Belongs to the IL-17 family | Interleukin-9; Supports IL-2 independent and IL-4 independent growth of helper T-cells; Interleukins | 0.910 |
