MTHFSD protein (human) - STRING database

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MTHFSD

Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing (383 aa)

Predicted Functional Partners:

EMC8

0.780

FOXF1

0.730

DEPDC5

0.696

FOXL1

0.677

MTHFS

0.673

GINS2

0.624

GCSH

0.593

MYCBPAP

0.577

ZNF821

0.572

COX4I1

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX4I1	EMC8	ENSP00000457513	ENSP00000253457	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	ER membrane protein complex subunit 8	0.914
COX4I1	GINS2	ENSP00000457513	ENSP00000253462	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	0.479
COX4I1	MTHFSD	ENSP00000457513	ENSP00000354152	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.544
DEPDC5	MTHFSD	ENSP00000383105	ENSP00000354152	GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.696
EMC8	COX4I1	ENSP00000253457	ENSP00000457513	ER membrane protein complex subunit 8	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	0.914
EMC8	FOXF1	ENSP00000253457	ENSP00000262426	ER membrane protein complex subunit 8	Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes; Forkhead boxes	0.407
EMC8	GINS2	ENSP00000253457	ENSP00000253462	ER membrane protein complex subunit 8	DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	0.781
EMC8	MTHFSD	ENSP00000253457	ENSP00000354152	ER membrane protein complex subunit 8	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.780
FOXF1	EMC8	ENSP00000262426	ENSP00000253457	Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes; Forkhead boxes	ER membrane protein complex subunit 8	0.407
FOXF1	MTHFSD	ENSP00000262426	ENSP00000354152	Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes; Forkhead boxes	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.730
FOXL1	MTHFSD	ENSP00000326272	ENSP00000354152	Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity); Forkhead boxes	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.677
GCSH	MTHFS	ENSP00000319531	ENSP00000258874	Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family	5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate	0.740
GCSH	MTHFSD	ENSP00000319531	ENSP00000354152	Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.593
GINS2	COX4I1	ENSP00000253462	ENSP00000457513	DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	0.479
GINS2	EMC8	ENSP00000253462	ENSP00000253457	DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	ER membrane protein complex subunit 8	0.781
GINS2	MTHFSD	ENSP00000253462	ENSP00000354152	DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.624
MTHFS	GCSH	ENSP00000258874	ENSP00000319531	5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate	Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST); Belongs to the GcvH family	0.740
MTHFS	MTHFSD	ENSP00000258874	ENSP00000354152	5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	0.673
MTHFSD	COX4I1	ENSP00000354152	ENSP00000457513	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport	0.544
MTHFSD	DEPDC5	ENSP00000354152	ENSP00000383105	Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing	GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway	0.696

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