• Version:
  • 11.0 [archived version]
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TCTE1 TCTE1 IQCA1 IQCA1 MDN1 MDN1 IQCD IQCD GAS8 GAS8 CCDC135 CCDC135 SOWAHD SOWAHD HMHA1 HMHA1 SAMD10 SAMD10 TAGAP TAGAP ANKDD1A ANKDD1A
"CCDC135" - Dynein regulatory complex subunit 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CCDC135Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family (874 aa)    
Predicted Functional Partners:
IQCD
IQ domain-containing protein D; Cilia and flagella associated (347 aa)
     
   
  0.753
ANKDD1A
Ankyrin repeat and death domain containing 1A (522 aa)
     
   
  0.750
GAS8
Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex (478 aa)
     
   
  0.719
IQCA1
IQ motif containing with AAA domain 1 (830 aa)
           
  0.702
TAGAP
T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation (731 aa)
           
  0.688
SOWAHD
Ankyrin repeat domain-containing protein SOWAHD; Sosondowah ankyrin repeat domain family member D; Belongs to the SOWAH family (315 aa)
           
  0.682
TCTE1
T-complex-associated-testis-expressed 1; Dynein regulatory complex (501 aa)
           
  0.680
HMHA1
Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity (1152 aa)
           
  0.653
SAMD10
Sterile alpha motif domain containing 10 (202 aa)
           
  0.648
MDN1
Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre- 60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] (5596 aa)
           
  0.648
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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