C15orf39 protein (human) - STRING database

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C15orf39

Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 (1047 aa)

Predicted Functional Partners:

RSRP1

0.696

MOB3A

0.558

ZNF407

0.531

DENND3

0.528

TMUB2

0.519

IER2

0.503

OR6C3

0.495

IGDCC4

0.473

SLC37A4

0.420

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf39	DENND3	ENSP00000353854	ENSP00000262585	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]	0.528
C15orf39	IER2	ENSP00000353854	ENSP00000465617	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Immediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis; Belongs to the IER family	0.503
C15orf39	IGDCC4	ENSP00000353854	ENSP00000319623	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.473
C15orf39	MOB3A	ENSP00000353854	ENSP00000349575	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators	0.558
C15orf39	OR6C3	ENSP00000353854	ENSP00000368989	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Olfactory receptor 6C3; Odorant receptor; Olfactory receptors, family 6	0.495
C15orf39	RSRP1	ENSP00000353854	ENSP00000243189	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Arginine and serine rich protein 1; Belongs to the RSRP family	0.696
C15orf39	SLC37A4	ENSP00000353854	ENSP00000476176	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Glucose-6-phosphate exchanger SLC37A4; Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6- phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family	0.420
C15orf39	TMUB2	ENSP00000353854	ENSP00000466971	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Transmembrane and ubiquitin like domain containing 2	0.519
C15orf39	ZNF407	ENSP00000353854	ENSP00000299687	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Zinc finger protein 407; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.531
DENND3	C15orf39	ENSP00000262585	ENSP00000353854	DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.528
DENND3	MOB3A	ENSP00000262585	ENSP00000349575	DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]	MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators	0.412
DENND3	TMUB2	ENSP00000262585	ENSP00000466971	DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]	Transmembrane and ubiquitin like domain containing 2	0.519
IER2	C15orf39	ENSP00000465617	ENSP00000353854	Immediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis; Belongs to the IER family	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.503
IGDCC4	C15orf39	ENSP00000319623	ENSP00000353854	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.473
MOB3A	C15orf39	ENSP00000349575	ENSP00000353854	MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.558
MOB3A	DENND3	ENSP00000349575	ENSP00000262585	MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators	DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...]	0.412
MOB3A	TMUB2	ENSP00000349575	ENSP00000466971	MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators	Transmembrane and ubiquitin like domain containing 2	0.400
OR6C3	C15orf39	ENSP00000368989	ENSP00000353854	Olfactory receptor 6C3; Odorant receptor; Olfactory receptors, family 6	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.495
RSRP1	C15orf39	ENSP00000243189	ENSP00000353854	Arginine and serine rich protein 1; Belongs to the RSRP family	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.696
SLC37A4	C15orf39	ENSP00000476176	ENSP00000353854	Glucose-6-phosphate exchanger SLC37A4; Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6- phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.420

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