node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L12 | PRR12 | ENSP00000482218 | ENSP00000394510 | Bcl-2-like protein 12; BCL2 like 12 | Proline-rich protein 12; Proline rich 12 | 0.706 |
BCL2L12 | PRRG2 | ENSP00000482218 | ENSP00000246794 | Bcl-2-like protein 12; BCL2 like 12 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.689 |
BCL2L12 | SCAF1 | ENSP00000482218 | ENSP00000353769 | Bcl-2-like protein 12; BCL2 like 12 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.707 |
COX7A2L | SCAF1 | ENSP00000367938 | ENSP00000353769 | Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity); Belongs to the cytochrome c oxidase VIIa family | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.652 |
DONSON | SCAF1 | ENSP00000307143 | ENSP00000353769 | Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.668 |
FAM168B | SCAF1 | ENSP00000387051 | ENSP00000353769 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.913 |
FAM168B | SRP72 | ENSP00000387051 | ENSP00000342181 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function; Belongs to the SRP72 family | 0.536 |
FAM168B | SRRM1 | ENSP00000387051 | ENSP00000326261 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3’-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.673 |
HECTD1 | SCAF1 | ENSP00000382269 | ENSP00000353769 | E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ’Lys-63’-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure; Belongs to the UPL family. K-HECT subfamily | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.839 |
HECTD1 | SRRM1 | ENSP00000382269 | ENSP00000326261 | E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ’Lys-63’-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure; Belongs to the UPL family. K-HECT subfamily | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3’-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.430 |
HECTD1 | SUPT6H | ENSP00000382269 | ENSP00000319104 | E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ’Lys-63’-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure; Belongs to the UPL family. K-HECT subfamily | Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H-IWS1-CTD complex r [...] | 0.649 |
PRR12 | BCL2L12 | ENSP00000394510 | ENSP00000482218 | Proline-rich protein 12; Proline rich 12 | Bcl-2-like protein 12; BCL2 like 12 | 0.706 |
PRR12 | PRRG2 | ENSP00000394510 | ENSP00000246794 | Proline-rich protein 12; Proline rich 12 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.857 |
PRR12 | SCAF1 | ENSP00000394510 | ENSP00000353769 | Proline-rich protein 12; Proline rich 12 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.909 |
PRRG2 | BCL2L12 | ENSP00000246794 | ENSP00000482218 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | Bcl-2-like protein 12; BCL2 like 12 | 0.689 |
PRRG2 | PRR12 | ENSP00000246794 | ENSP00000394510 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | Proline-rich protein 12; Proline rich 12 | 0.857 |
PRRG2 | SCAF1 | ENSP00000246794 | ENSP00000353769 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | 0.808 |
SCAF1 | BCL2L12 | ENSP00000353769 | ENSP00000482218 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | Bcl-2-like protein 12; BCL2 like 12 | 0.707 |
SCAF1 | COX7A2L | ENSP00000353769 | ENSP00000367938 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity); Belongs to the cytochrome c oxidase VIIa family | 0.652 |
SCAF1 | DONSON | ENSP00000353769 | ENSP00000307143 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing | Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability | 0.668 |