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HECTD1 HECTD1 SRP72 SRP72 SRRM1 SRRM1 SUPT6H SUPT6H FAM168B FAM168B SCAF1 SCAF1 COX7A2L COX7A2L PRR12 PRR12 BCL2L12 BCL2L12 PRRG2 PRRG2 DONSON DONSON
"SCAF1" - Splicing factor, arginine/serine-rich 19 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCAF1Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing (1312 aa)    
Predicted Functional Partners:
FAM168B
Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) (195 aa)
     
        0.913
PRR12
Proline-rich protein 12; Proline rich 12 (2036 aa)
 
 
   
  0.909
SRRM1
Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3’-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] (904 aa)
     
        0.897
SUPT6H
Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H-IWS1-CTD complex r [...] (1726 aa)
     
        0.845
HECTD1
E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ’Lys-63’-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure; Belongs to the UPL family. K-HECT subfamily (2610 aa)
     
   
  0.839
SRP72
Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function; Belongs to the SRP72 family (671 aa)
     
        0.819
PRRG2
Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing (202 aa)
           
  0.808
BCL2L12
Bcl-2-like protein 12; BCL2 like 12 (334 aa)
     
   
  0.707
DONSON
Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability (566 aa)
     
   
  0.668
COX7A2L
Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity); Belongs to the cytochrome c oxidase VIIa family (114 aa)
           
  0.652
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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