| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCORL1 | ZNF528 | ENSP00000437775 | ENSP00000353652 | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor; Belongs to the BCOR family | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.405 |
| CECR2 | ZNF528 | ENSP00000341219 | ENSP00000353652 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex. It thereby plays a role in various processes during development- required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated. May also be invo [...] | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.405 |
| TRIM28 | ZNF528 | ENSP00000253024 | ENSP00000353652 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.909 |
| URGCP | WDFY1 | ENSP00000396918 | ENSP00000233055 | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer | WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines; WD repeat domain containing | 0.497 |
| URGCP | ZNF528 | ENSP00000396918 | ENSP00000353652 | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.422 |
| WDFY1 | URGCP | ENSP00000233055 | ENSP00000396918 | WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines; WD repeat domain containing | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer | 0.497 |
| WDFY1 | ZNF528 | ENSP00000233055 | ENSP00000353652 | WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines; WD repeat domain containing | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.427 |
| ZNF528 | BCORL1 | ENSP00000353652 | ENSP00000437775 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor; Belongs to the BCOR family | 0.405 |
| ZNF528 | CECR2 | ENSP00000353652 | ENSP00000341219 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex. It thereby plays a role in various processes during development- required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated. May also be invo [...] | 0.405 |
| ZNF528 | TRIM28 | ENSP00000353652 | ENSP00000253024 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.909 |
| ZNF528 | URGCP | ENSP00000353652 | ENSP00000396918 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer | 0.422 |
| ZNF528 | WDFY1 | ENSP00000353652 | ENSP00000233055 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type | WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines; WD repeat domain containing | 0.427 |
