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  • 11.0 [archived version]
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NUDT13 NUDT13 SERINC1 SERINC1 NCOA7 NCOA7 DTWD2 DTWD2 CNOT6L CNOT6L VAPA VAPA ZNF460 ZNF460 LMOD1 LMOD1 ZNF321P ZNF321P TRIM28 TRIM28 ZNF69 ZNF69
"ZNF460" - Zinc finger protein 460 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ZNF460Zinc finger protein 460; May be involved in transcriptional regulation; Zinc fingers C2H2-type (562 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.925
LMOD1
Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family (600 aa)
           
  0.711
SERINC1
Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family (453 aa)
       
 
  0.632
CNOT6L
CCR4-NOT transcription complex subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3’ [...] (555 aa)
       
 
  0.585
ZNF321P
Putative protein ZNF321; Zinc finger protein 321, pseudogene (233 aa)
           
  0.581
DTWD2
DTW domain containing 2 (298 aa)
           
  0.562
NUDT13
Nucleoside diphosphate-linked moiety X motif 13; Nudix hydrolase family (352 aa)
       
 
  0.552
VAPA
Vesicle-associated membrane protein-associated protein A; VAMP associated protein A (294 aa)
       
 
  0.493
NCOA7
Nuclear receptor coactivator 7; Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA; Belongs to the OXR1 family (942 aa)
     
 
  0.489
ZNF69
Zinc finger protein 69; Zinc fingers C2H2-type (149 aa)
           
  0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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