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STRINGSTRING
ANKRD20A1 ANKRD20A1 ANKRD20A2 ANKRD20A2 SETD2 SETD2 FAM72C FAM72C ANKRD20A4 ANKRD20A4 WASH2P WASH2P CBWD3 CBWD3 HSPB3 HSPB3 SASH3 SASH3 KIF22 KIF22 CCDC77 CCDC77
"CBWD3" - COBW domain containing 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBWD3COBW domain containing 3 (395 aa)    
Predicted Functional Partners:
SETD2
Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates ’Lys-36’ of histone H3 (H3K36me3) using dimethylated ’Lys-36’ (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recr [...] (2564 aa)
      
   
  0.643
KIF22
Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80- depleted cells; Kinesins (665 aa)
            
  0.585
WASH2P
WAS protein family homolog 2; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and invo [...] (464 aa)
            
  0.572
ANKRD20A1
Ankyrin repeat domain-containing protein 20A1; Ankyrin repeat domain 20 family member A1 (823 aa)
      
   
  0.539
ANKRD20A2
Ankyrin repeat domain-containing protein 20A2; Ankyrin repeat domain 20 family member A2 (823 aa)
      
   
  0.539
ANKRD20A4
Ankyrin repeat domain-containing protein 20A4; Ankyrin repeat domain 20 family member A4 (823 aa)
      
   
  0.539
HSPB3
Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins (150 aa)
            
  0.529
FAM72C
Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family (149 aa)
            
  0.514
CCDC77
Coiled-coil domain containing 77 (488 aa)
            
  0.482
SASH3
SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes; SAM and SH3 domain containing (380 aa)
            
  0.430
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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