SDF4 protein (human) - STRING database

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SDF4

45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family (362 aa)

Predicted Functional Partners:

CALB1

0.836

PVALB

0.831

CALB2

0.740

S100G

0.670

S100B

0.669

STXBP2

0.657

MEGF6

0.645

LANCL1

0.643

ATP2C1

0.595

S100A4

0.587

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2C1	SDF4	ENSP00000421326	ENSP00000353094	Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.595
CALB1	PVALB	ENSP00000265431	ENSP00000216200	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	0.945
CALB1	S100B	ENSP00000265431	ENSP00000291700	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	0.555
CALB1	S100G	ENSP00000265431	ENSP00000369547	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	S100 calcium binding protein G; Belongs to the S-100 family	0.764
CALB1	SDF4	ENSP00000265431	ENSP00000353094	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.836
CALB2	PVALB	ENSP00000307508	ENSP00000216200	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	0.944
CALB2	S100B	ENSP00000307508	ENSP00000291700	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	0.472
CALB2	S100G	ENSP00000307508	ENSP00000369547	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	S100 calcium binding protein G; Belongs to the S-100 family	0.549
CALB2	SDF4	ENSP00000307508	ENSP00000353094	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.740
LANCL1	SDF4	ENSP00000388713	ENSP00000353094	LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.643
MEGF6	SDF4	ENSP00000348982	ENSP00000353094	Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.645
PVALB	CALB1	ENSP00000216200	ENSP00000265431	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	0.945
PVALB	CALB2	ENSP00000216200	ENSP00000307508	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	0.944
PVALB	S100B	ENSP00000216200	ENSP00000291700	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	0.635
PVALB	S100G	ENSP00000216200	ENSP00000369547	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	S100 calcium binding protein G; Belongs to the S-100 family	0.616
PVALB	SDF4	ENSP00000216200	ENSP00000353094	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.831
S100A4	S100B	ENSP00000357705	ENSP00000291700	S100 calcium binding protein A4; EF-hand domain containing	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	0.770
S100A4	SDF4	ENSP00000357705	ENSP00000353094	S100 calcium binding protein A4; EF-hand domain containing	45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family	0.587
S100B	CALB1	ENSP00000291700	ENSP00000265431	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase; EF-hand domain containing	0.555
S100B	CALB2	ENSP00000291700	ENSP00000307508	Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic p [...]	Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing	0.472

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