| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNTNAP5 | ZNF517 | ENSP00000399013 | ENSP00000353058 | Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
| COMMD5 | ZNF517 | ENSP00000394331 | ENSP00000353058 | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B; COMM domain containing | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.497 |
| DNAAF1 | ZNF517 | ENSP00000367815 | ENSP00000353058 | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.413 |
| MPV17L2 | SYAP1 | ENSP00000469836 | ENSP00000369500 | Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis; Belongs to the peroxisomal membrane protein PXMP2/4 family | Synapse associated protein 1 | 0.474 |
| MPV17L2 | ZNF517 | ENSP00000469836 | ENSP00000353058 | Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis; Belongs to the peroxisomal membrane protein PXMP2/4 family | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.530 |
| RPL8 | ZNF517 | ENSP00000262584 | ENSP00000353058 | 60S ribosomal protein L8; Component of the large ribosomal subunit | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.674 |
| STK36 | ZNF517 | ENSP00000295709 | ENSP00000353058 | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.414 |
| SYAP1 | MPV17L2 | ENSP00000369500 | ENSP00000469836 | Synapse associated protein 1 | Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis; Belongs to the peroxisomal membrane protein PXMP2/4 family | 0.474 |
| SYAP1 | ZNF517 | ENSP00000369500 | ENSP00000353058 | Synapse associated protein 1 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.513 |
| TRIM28 | ZNF517 | ENSP00000253024 | ENSP00000353058 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.940 |
| ZNF517 | CNTNAP5 | ENSP00000353058 | ENSP00000399013 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication | 0.420 |
| ZNF517 | COMMD5 | ENSP00000353058 | ENSP00000394331 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B; COMM domain containing | 0.497 |
| ZNF517 | DNAAF1 | ENSP00000353058 | ENSP00000367815 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli | 0.413 |
| ZNF517 | MPV17L2 | ENSP00000353058 | ENSP00000469836 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis; Belongs to the peroxisomal membrane protein PXMP2/4 family | 0.530 |
| ZNF517 | RPL8 | ENSP00000353058 | ENSP00000262584 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 60S ribosomal protein L8; Component of the large ribosomal subunit | 0.674 |
| ZNF517 | STK36 | ENSP00000353058 | ENSP00000295709 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.414 |
| ZNF517 | SYAP1 | ENSP00000353058 | ENSP00000369500 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Synapse associated protein 1 | 0.513 |
| ZNF517 | TRIM28 | ENSP00000353058 | ENSP00000253024 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.940 |
