node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CES1 | CLEC14A | ENSP00000353720 | ENSP00000353013 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate; Carboxylesterases | C-type lectin domain containing 14A | 0.755 |
CES1 | RNGTT | ENSP00000353720 | ENSP00000358497 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate; Carboxylesterases | mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5’- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation- by removing the gamma-phosphate from the 5’-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5’-diphosphate terminus | 0.711 |
CES1 | RNMT | ENSP00000353720 | ENSP00000372804 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate; Carboxylesterases | mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT-RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5’-cap structure of mRNAs. Binds RNA containing 5’-terminal GpppC | 0.606 |
CLDN5 | CLEC14A | ENSP00000385477 | ENSP00000353013 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | C-type lectin domain containing 14A | 0.560 |
CLDN5 | ROBO4 | ENSP00000385477 | ENSP00000304945 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity); Belongs to the immunoglobulin superfamily. ROBO family | 0.448 |
CLDN5 | TMEM204 | ENSP00000385477 | ENSP00000454945 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens | 0.628 |
CLDN5 | VWF | ENSP00000385477 | ENSP00000261405 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma; Endogenous ligands | 0.895 |
CLEC14A | CES1 | ENSP00000353013 | ENSP00000353720 | C-type lectin domain containing 14A | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate; Carboxylesterases | 0.755 |
CLEC14A | CLDN5 | ENSP00000353013 | ENSP00000385477 | C-type lectin domain containing 14A | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.560 |
CLEC14A | ECSCR | ENSP00000353013 | ENSP00000479243 | C-type lectin domain containing 14A | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2; Belongs to the ECSCR family | 0.583 |
CLEC14A | MLF2 | ENSP00000353013 | ENSP00000203630 | C-type lectin domain containing 14A | Myeloid leukemia factor 2 | 0.607 |
CLEC14A | MMRN2 | ENSP00000353013 | ENSP00000361097 | C-type lectin domain containing 14A | Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA; EMI domain containing | 0.868 |
CLEC14A | RNGTT | ENSP00000353013 | ENSP00000358497 | C-type lectin domain containing 14A | mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5’- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation- by removing the gamma-phosphate from the 5’-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5’-diphosphate terminus | 0.904 |
CLEC14A | RNMT | ENSP00000353013 | ENSP00000372804 | C-type lectin domain containing 14A | mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT-RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5’-cap structure of mRNAs. Binds RNA containing 5’-terminal GpppC | 0.801 |
CLEC14A | ROBO4 | ENSP00000353013 | ENSP00000304945 | C-type lectin domain containing 14A | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity); Belongs to the immunoglobulin superfamily. ROBO family | 0.668 |
CLEC14A | TMEM204 | ENSP00000353013 | ENSP00000454945 | C-type lectin domain containing 14A | Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens | 0.573 |
CLEC14A | VWF | ENSP00000353013 | ENSP00000261405 | C-type lectin domain containing 14A | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma; Endogenous ligands | 0.709 |
ECSCR | CLEC14A | ENSP00000479243 | ENSP00000353013 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2; Belongs to the ECSCR family | C-type lectin domain containing 14A | 0.583 |
ECSCR | ROBO4 | ENSP00000479243 | ENSP00000304945 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2; Belongs to the ECSCR family | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity); Belongs to the immunoglobulin superfamily. ROBO family | 0.645 |
MLF2 | CLEC14A | ENSP00000203630 | ENSP00000353013 | Myeloid leukemia factor 2 | C-type lectin domain containing 14A | 0.607 |