| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BZW1 | C2orf69 | ENSP00000394316 | ENSP00000312770 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | 0.445 |
| BZW1 | KCTD18 | ENSP00000394316 | ENSP00000352941 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.679 |
| BZW1 | SPATS2L | ENSP00000394316 | ENSP00000482515 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.738 |
| BZW1 | TYW5 | ENSP00000394316 | ENSP00000346627 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.732 |
| C2orf69 | BZW1 | ENSP00000312770 | ENSP00000394316 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly | 0.445 |
| C2orf69 | KCTD18 | ENSP00000312770 | ENSP00000352941 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.559 |
| C2orf69 | SPATS2L | ENSP00000312770 | ENSP00000482515 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family | 0.599 |
| C2orf69 | TYW5 | ENSP00000312770 | ENSP00000346627 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.609 |
| KCNG2 | KCNK16 | ENSP00000315654 | ENSP00000391498 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | 0.506 |
| KCNG2 | KCNK17 | ENSP00000315654 | ENSP00000362328 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | 0.545 |
| KCNG2 | KCTD18 | ENSP00000315654 | ENSP00000352941 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.592 |
| KCNK16 | KCNG2 | ENSP00000391498 | ENSP00000315654 | Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | 0.506 |
| KCNK16 | KCTD18 | ENSP00000391498 | ENSP00000352941 | Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.598 |
| KCNK17 | KCNG2 | ENSP00000362328 | ENSP00000315654 | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | 0.545 |
| KCNK17 | KCTD11 | ENSP00000362328 | ENSP00000328352 | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | 0.434 |
| KCNK17 | KCTD18 | ENSP00000362328 | ENSP00000352941 | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.558 |
| KCNK17 | KCTD20 | ENSP00000362328 | ENSP00000362836 | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members | 0.661 |
| KCTD11 | KCNK17 | ENSP00000328352 | ENSP00000362328 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | 0.434 |
| KCTD11 | KCTD18 | ENSP00000328352 | ENSP00000352941 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 | 0.591 |
| KCTD11 | KCTD20 | ENSP00000328352 | ENSP00000362836 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members | 0.644 |
