SPINK5 protein (human) - STRING database

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SPINK5

Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type (1094 aa)

Predicted Functional Partners:

KLK5

0.972

CELA2A

0.905

KLK14

0.836

FLG

0.819

ST14

0.752

SPINK6

0.749

KLK7

0.733

SPINK2

0.706

DSG1

0.688

CDSN

0.681

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDSN	DSG1	ENSP00000365465	ENSP00000257192	Corneodesmosin; Important for the epidermal barrier integrity	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	0.738
CDSN	FLG	ENSP00000365465	ENSP00000357789	Corneodesmosin; Important for the epidermal barrier integrity	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.676
CDSN	KLK14	ENSP00000365465	ENSP00000375678	Corneodesmosin; Important for the epidermal barrier integrity	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	0.677
CDSN	KLK5	ENSP00000365465	ENSP00000337733	Corneodesmosin; Important for the epidermal barrier integrity	Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily	0.650
CDSN	KLK7	ENSP00000365465	ENSP00000375683	Corneodesmosin; Important for the epidermal barrier integrity	Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at ’14-Tyr-\|-Gln-15’ and insulin B chain at ’6- Leu-\|-Cys-7’, ’16-Tyr-\|-Leu-17’, ’25-Phe-\|-Tyr-26’ and ’26-Tyr-\|- Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines; Kallikreins	0.791
CDSN	SPINK5	ENSP00000365465	ENSP00000352936	Corneodesmosin; Important for the epidermal barrier integrity	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	0.681
CELA2A	DSG1	ENSP00000352639	ENSP00000257192	Chymotrypsin-like elastase family member 2A; Acts upon elastin	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	0.902
CELA2A	FLG	ENSP00000352639	ENSP00000357789	Chymotrypsin-like elastase family member 2A; Acts upon elastin	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.900
CELA2A	KLK5	ENSP00000352639	ENSP00000337733	Chymotrypsin-like elastase family member 2A; Acts upon elastin	Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily	0.913
CELA2A	SPINK5	ENSP00000352639	ENSP00000352936	Chymotrypsin-like elastase family member 2A; Acts upon elastin	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	0.905
DSG1	CDSN	ENSP00000257192	ENSP00000365465	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Corneodesmosin; Important for the epidermal barrier integrity	0.738
DSG1	CELA2A	ENSP00000257192	ENSP00000352639	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Chymotrypsin-like elastase family member 2A; Acts upon elastin	0.902
DSG1	FLG	ENSP00000257192	ENSP00000357789	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing	0.966
DSG1	KLK14	ENSP00000257192	ENSP00000375678	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...]	0.521
DSG1	KLK5	ENSP00000257192	ENSP00000337733	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily	0.973
DSG1	KLK7	ENSP00000257192	ENSP00000375683	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at ’14-Tyr-\|-Gln-15’ and insulin B chain at ’6- Leu-\|-Cys-7’, ’16-Tyr-\|-Leu-17’, ’25-Phe-\|-Tyr-26’ and ’26-Tyr-\|- Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines; Kallikreins	0.666
DSG1	SPINK2	ENSP00000257192	ENSP00000425961	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Serine peptidase inhibitor, Kazal type 2	0.431
DSG1	SPINK5	ENSP00000257192	ENSP00000352936	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	0.688
DSG1	SPINK6	ENSP00000257192	ENSP00000324870	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	0.417
DSG1	ST14	ENSP00000257192	ENSP00000278742	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins	Suppressor of tumorigenicity 14 protein; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing; Serine proteases	0.480

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