• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM63B TMEM63B NSFL1C NSFL1C ARHGAP20 ARHGAP20 ARMCX2 ARMCX2 SEMA4A SEMA4A SIRPB2 SIRPB2 FCRL2 FCRL2 SUSD3 SUSD3 FAM102A FAM102A OXNAD1 OXNAD1 METRNL METRNL
"SIRPB2" - Signal-regulatory protein beta-2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIRPB2Signal-regulatory protein beta-2; Signal regulatory protein beta 2 (342 aa)    
Predicted Functional Partners:
OXNAD1
Oxidoreductase NAD-binding domain-containing protein 1; Oxidoreductase NAD binding domain containing 1 (312 aa)
           
  0.539
SUSD3
Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration; Sushi domain containing (255 aa)
           
  0.530
FAM102A
Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family (384 aa)
           
  0.528
ARMCX2
Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing (632 aa)
           
  0.506
ARHGAP20
Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (1191 aa)
           
  0.506
SEMA4A
Semaphorin-4A; Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity); Semaphorins (761 aa)
     
   
  0.461
TMEM63B
CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel (832 aa)
     
   
  0.459
FCRL2
Fc receptor-like protein 2; May have an regulatory role in normal and neoplastic B cell development; CD molecules (508 aa)
     
   
  0.453
NSFL1C
NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family (372 aa)
           
  0.451
METRNL
Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates a [...] (311 aa)
           
  0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]