node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CELA2A | CPB1 | ENSP00000352639 | ENSP00000417222 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | M14 carboxypeptidases; Belongs to the peptidase M14 family | 0.945 |
CELA2A | DSC1 | ENSP00000352639 | ENSP00000257198 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | 0.905 |
CELA2A | DSC2 | ENSP00000352639 | ENSP00000280904 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | 0.901 |
CELA2A | DSC3 | ENSP00000352639 | ENSP00000353608 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | 0.901 |
CELA2A | DSG1 | ENSP00000352639 | ENSP00000257192 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.902 |
CELA2A | DSG2 | ENSP00000352639 | ENSP00000261590 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.902 |
CELA2A | DSG4 | ENSP00000352639 | ENSP00000352785 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity); Desmosomal cadherins | 0.902 |
CELA2A | KLK5 | ENSP00000352639 | ENSP00000337733 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily | 0.913 |
CELA2A | PKP2 | ENSP00000352639 | ENSP00000070846 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | 0.900 |
CELA2A | SPINK5 | ENSP00000352639 | ENSP00000352936 | Chymotrypsin-like elastase family member 2A; Acts upon elastin | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.905 |
CPB1 | CELA2A | ENSP00000417222 | ENSP00000352639 | M14 carboxypeptidases; Belongs to the peptidase M14 family | Chymotrypsin-like elastase family member 2A; Acts upon elastin | 0.945 |
DSC1 | CELA2A | ENSP00000257198 | ENSP00000352639 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Chymotrypsin-like elastase family member 2A; Acts upon elastin | 0.905 |
DSC1 | DSC2 | ENSP00000257198 | ENSP00000280904 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | 0.905 |
DSC1 | DSC3 | ENSP00000257198 | ENSP00000353608 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | 0.905 |
DSC1 | DSG1 | ENSP00000257198 | ENSP00000257192 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.952 |
DSC1 | DSG2 | ENSP00000257198 | ENSP00000261590 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins | 0.946 |
DSC1 | DSG4 | ENSP00000257198 | ENSP00000352785 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity); Desmosomal cadherins | 0.910 |
DSC1 | KLK5 | ENSP00000257198 | ENSP00000337733 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily | 0.956 |
DSC1 | PKP2 | ENSP00000257198 | ENSP00000070846 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | 0.989 |
DSC1 | SPINK5 | ENSP00000257198 | ENSP00000352936 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.526 |