CGB2 protein (human) - STRING database

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CGB2

Chorionic gonadotropin beta subunit 2 (163 aa)

Predicted Functional Partners:

ACTL7A

0.589

ABI2

0.581

ODF4

0.571

MAGEB4

0.540

CYFIP1

0.535

WASF1

0.535

TSGA10

0.473

HTRA4

0.448

CGB1

0.424

OIP5

0.412

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI2	CGB2	ENSP00000295851	ENSP00000352295	Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)	Chorionic gonadotropin beta subunit 2	0.581
ABI2	CYFIP1	ENSP00000295851	ENSP00000481038	Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)	Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...]	0.999
ABI2	WASF1	ENSP00000295851	ENSP00000376368	Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)	Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity); A-kinase anchoring proteins	0.999
ACTL7A	CGB2	ENSP00000334300	ENSP00000352295	Actin-like protein 7A; Actin related proteins; Belongs to the actin family	Chorionic gonadotropin beta subunit 2	0.589
ACTL7A	MAGEB4	ENSP00000334300	ENSP00000368266	Actin-like protein 7A; Actin related proteins; Belongs to the actin family	Melanoma-associated antigen B4; MAGE family member B4	0.478
ACTL7A	ODF4	ENSP00000334300	ENSP00000331086	Actin-like protein 7A; Actin related proteins; Belongs to the actin family	Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton	0.549
ACTL7A	TSGA10	ENSP00000334300	ENSP00000377123	Actin-like protein 7A; Actin related proteins; Belongs to the actin family	Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family	0.426
CGB1	CGB2	ENSP00000301407	ENSP00000352295	Chorionic gonadotropin beta subunit 1	Chorionic gonadotropin beta subunit 2	0.424
CGB2	ABI2	ENSP00000352295	ENSP00000295851	Chorionic gonadotropin beta subunit 2	Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)	0.581
CGB2	ACTL7A	ENSP00000352295	ENSP00000334300	Chorionic gonadotropin beta subunit 2	Actin-like protein 7A; Actin related proteins; Belongs to the actin family	0.589
CGB2	CGB1	ENSP00000352295	ENSP00000301407	Chorionic gonadotropin beta subunit 2	Chorionic gonadotropin beta subunit 1	0.424
CGB2	CYFIP1	ENSP00000352295	ENSP00000481038	Chorionic gonadotropin beta subunit 2	Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...]	0.535
CGB2	HTRA4	ENSP00000352295	ENSP00000305919	Chorionic gonadotropin beta subunit 2	Serine protease HTRA4; Serine protease; PDZ domain containing	0.448
CGB2	MAGEB4	ENSP00000352295	ENSP00000368266	Chorionic gonadotropin beta subunit 2	Melanoma-associated antigen B4; MAGE family member B4	0.540
CGB2	ODF4	ENSP00000352295	ENSP00000331086	Chorionic gonadotropin beta subunit 2	Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton	0.571
CGB2	OIP5	ENSP00000352295	ENSP00000220514	Chorionic gonadotropin beta subunit 2	Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family	0.412
CGB2	TSGA10	ENSP00000352295	ENSP00000377123	Chorionic gonadotropin beta subunit 2	Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family	0.473
CGB2	WASF1	ENSP00000352295	ENSP00000376368	Chorionic gonadotropin beta subunit 2	Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity); A-kinase anchoring proteins	0.535
CYFIP1	ABI2	ENSP00000481038	ENSP00000295851	Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...]	Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)	0.999
CYFIP1	CGB2	ENSP00000481038	ENSP00000352295	Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the [...]	Chorionic gonadotropin beta subunit 2	0.535

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