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STRINGSTRING
ANKRD23 ANKRD23 LDB3 LDB3 NEBL NEBL TCAP TCAP TTN TTN NEB NEB ANKRD1 ANKRD1 ACTN2 ACTN2 MYPN MYPN TNNT2 TNNT2 PBLD PBLD
"MYPN" - Myopalladin in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MYPNMyopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family (1320 aa)    
Predicted Functional Partners:
NEB
Nebulin (8560 aa)
      
 
  0.904
ANKRD1
Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells; Ankyrin repeat domain containing (319 aa)
      
 
  0.871
ACTN2
Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins (894 aa)
      
 
  0.828
NEBL
Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion; LIM domain containing (1014 aa)
      
 
  0.817
LDB3
LIM domain-binding protein 3; LIM domain containing (732 aa)
      
   
  0.753
PBLD
Phenazine biosynthesis like protein domain containing (288 aa)
            
  0.724
TCAP
Telethonin; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (167 aa)
      
   
  0.715
ANKRD23
Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression; Ankyrin repeat domain containing (305 aa)
      
 
  0.663
TNNT2
Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (298 aa)
      
   
  0.648
TTN
Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Fibronectin type III domain containing (35991 aa)
      
 
0.647
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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