node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPY19L4 | FAM114A1 | ENSP00000389630 | ENSP00000351740 | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.582 |
DPY19L4 | FAM134A | ENSP00000389630 | ENSP00000395249 | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family | 0.683 |
DPY19L4 | FAM134C | ENSP00000389630 | ENSP00000309432 | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | 0.718 |
FAM114A1 | DPY19L4 | ENSP00000351740 | ENSP00000389630 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | 0.582 |
FAM114A1 | FAM134A | ENSP00000351740 | ENSP00000395249 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family | 0.558 |
FAM114A1 | FAM134C | ENSP00000351740 | ENSP00000309432 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | 0.596 |
FAM114A1 | KLB | ENSP00000351740 | ENSP00000257408 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) | 0.625 |
FAM114A1 | KLHL5 | ENSP00000351740 | ENSP00000423897 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Kelch-like protein 5; Kelch like family member 5; BTB domain containing | 0.619 |
FAM114A1 | LIAS | ENSP00000351740 | ENSP00000261434 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | 0.633 |
FAM114A1 | PDS5A | ENSP00000351740 | ENSP00000303427 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair; Belongs to the PDS5 family | 0.629 |
FAM114A1 | RFC1 | ENSP00000351740 | ENSP00000371321 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA; AAA ATPases | 0.687 |
FAM114A1 | RPL9 | ENSP00000351740 | ENSP00000400467 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | L ribosomal proteins | 0.546 |
FAM114A1 | TMEM156 | ENSP00000351740 | ENSP00000371364 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Transmembrane protein 156 | 0.750 |
FAM134A | DPY19L4 | ENSP00000395249 | ENSP00000389630 | Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | 0.683 |
FAM134A | FAM114A1 | ENSP00000395249 | ENSP00000351740 | Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.558 |
FAM134C | DPY19L4 | ENSP00000309432 | ENSP00000389630 | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins | 0.718 |
FAM134C | FAM114A1 | ENSP00000309432 | ENSP00000351740 | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.596 |
KLB | FAM114A1 | ENSP00000257408 | ENSP00000351740 | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.625 |
KLB | KLHL5 | ENSP00000257408 | ENSP00000423897 | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) | Kelch-like protein 5; Kelch like family member 5; BTB domain containing | 0.422 |
KLB | LIAS | ENSP00000257408 | ENSP00000261434 | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | 0.550 |