• Version:
  • 11.0 [archived version]
STRINGSTRING
KLHL5 KLHL5 PDS5A PDS5A RPL9 RPL9 TMEM156 TMEM156 KLB KLB FAM134A FAM134A FAM114A1 FAM114A1 LIAS LIAS RFC1 RFC1 DPY19L4 DPY19L4 FAM134C FAM134C
"FAM114A1" - Protein NOXP20 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM114A1Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family (563 aa)    
Predicted Functional Partners:
TMEM156
Transmembrane protein 156 (296 aa)
           
  0.750
RFC1
Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA; AAA ATPases (1148 aa)
           
  0.687
LIAS
Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (372 aa)
     
   
  0.633
PDS5A
Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair; Belongs to the PDS5 family (1337 aa)
           
  0.629
KLB
Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) (1044 aa)
           
  0.625
KLHL5
Kelch-like protein 5; Kelch like family member 5; BTB domain containing (755 aa)
           
  0.619
FAM134C
Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family (466 aa)
           
  0.596
DPY19L4
Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (723 aa)
           
  0.582
FAM134A
Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family (543 aa)
           
  0.558
RPL9
L ribosomal proteins (192 aa)
           
  0.546
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]