node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADO | FAM76B | ENSP00000362888 | ENSP00000351631 | 2-aminoethanethiol dioxygenase | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.513 |
CEP57 | FAM76B | ENSP00000317902 | ENSP00000351631 | Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.494 |
FAM76B | ADO | ENSP00000351631 | ENSP00000362888 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 2-aminoethanethiol dioxygenase | 0.513 |
FAM76B | CEP57 | ENSP00000351631 | ENSP00000317902 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | 0.494 |
FAM76B | KHDRBS3 | ENSP00000351631 | ENSP00000348108 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5’-[AU]UAAA-3’ motif in vitro. Binds optimally to RNA containing 5’-[AU]UAA-3’ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct [...] | 0.621 |
FAM76B | MROH1 | ENSP00000351631 | ENSP00000435565 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | Maestro heat like repeat family member 1 | 0.515 |
FAM76B | PHC2 | ENSP00000351631 | ENSP00000257118 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility; Sterile alpha motif domain containing | 0.517 |
FAM76B | RWDD2A | ENSP00000351631 | ENSP00000358739 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | RWD domain containing 2A | 0.442 |
FAM76B | SLC7A9 | ENSP00000351631 | ENSP00000023064 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule; Belongs to the amino acid-polyamine-organocation (APC) superfamily | 0.426 |
FAM76B | SRPK2 | ENSP00000351631 | ENSP00000377262 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.515 |
FAM76B | TTC23 | ENSP00000351631 | ENSP00000377690 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | Tetratricopeptide repeat domain containing | 0.510 |
FAM76B | ZBTB45 | ENSP00000351631 | ENSP00000469089 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity); BTB domain containing | 0.559 |
KHDRBS3 | FAM76B | ENSP00000348108 | ENSP00000351631 | KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5’-[AU]UAAA-3’ motif in vitro. Binds optimally to RNA containing 5’-[AU]UAA-3’ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct [...] | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.621 |
MROH1 | FAM76B | ENSP00000435565 | ENSP00000351631 | Maestro heat like repeat family member 1 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.515 |
PHC2 | FAM76B | ENSP00000257118 | ENSP00000351631 | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility; Sterile alpha motif domain containing | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.517 |
PHC2 | ZBTB45 | ENSP00000257118 | ENSP00000469089 | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility; Sterile alpha motif domain containing | Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity); BTB domain containing | 0.403 |
RWDD2A | FAM76B | ENSP00000358739 | ENSP00000351631 | RWD domain containing 2A | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.442 |
RWDD2A | SRPK2 | ENSP00000358739 | ENSP00000377262 | RWD domain containing 2A | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.442 |
SLC7A9 | FAM76B | ENSP00000023064 | ENSP00000351631 | B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule; Belongs to the amino acid-polyamine-organocation (APC) superfamily | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.426 |
SRPK2 | FAM76B | ENSP00000377262 | ENSP00000351631 | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family | 0.515 |