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PHC2 PHC2 ZBTB45 ZBTB45 TTC23 TTC23 MROH1 MROH1 FAM76B FAM76B ADO ADO SLC7A9 SLC7A9 KHDRBS3 KHDRBS3 CEP57 CEP57 SRPK2 SRPK2 RWDD2A RWDD2A
"FAM76B" - Protein FAM76B in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FAM76BProtein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family (339 aa)    
Predicted Functional Partners:
KHDRBS3
KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5’-[AU]UAAA-3’ motif in vitro. Binds optimally to RNA containing 5’-[AU]UAA-3’ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct [...] (346 aa)
           
  0.621
ZBTB45
Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity); BTB domain containing (511 aa)
           
  0.559
PHC2
Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility; Sterile alpha motif domain containing (858 aa)
     
   
  0.517
MROH1
Maestro heat like repeat family member 1 (1641 aa)
           
  0.515
SRPK2
SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] (699 aa)
     
 
  0.515
ADO
2-aminoethanethiol dioxygenase (270 aa)
       
      0.513
TTC23
Tetratricopeptide repeat domain containing (447 aa)
           
  0.510
CEP57
Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 (500 aa)
     
   
  0.494
RWDD2A
RWD domain containing 2A (292 aa)
       
      0.442
SLC7A9
B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule; Belongs to the amino acid-polyamine-organocation (APC) superfamily (487 aa)
           
  0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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