| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALK | FAM150A | ENSP00000373700 | ENSP00000351345 | ALK tyrosine kinase receptor; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y- x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as o [...] | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.557 |
| DIO1 | FAM150A | ENSP00000354643 | ENSP00000351345 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine) and of T3 into T2 (3,3’-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.712 |
| DIO1 | GPBAR1 | ENSP00000354643 | ENSP00000430886 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine) and of T3 into T2 (3,3’-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | 0.715 |
| DIO1 | SECISBP2 | ENSP00000354643 | ENSP00000364965 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine) and of T3 into T2 (3,3’-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney | Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.473 |
| DIO2 | FAM150A | ENSP00000450980 | ENSP00000351345 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.624 |
| DIO2 | GPBAR1 | ENSP00000450980 | ENSP00000430886 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | 0.756 |
| DIO2 | SECISBP2 | ENSP00000450980 | ENSP00000364965 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins | Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.804 |
| FAM150A | ALK | ENSP00000351345 | ENSP00000373700 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | ALK tyrosine kinase receptor; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y- x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as o [...] | 0.557 |
| FAM150A | DIO1 | ENSP00000351345 | ENSP00000354643 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine) and of T3 into T2 (3,3’-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney | 0.712 |
| FAM150A | DIO2 | ENSP00000351345 | ENSP00000450980 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine); Selenoproteins | 0.624 |
| FAM150A | FAM78A | ENSP00000351345 | ENSP00000361345 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | 0.591 |
| FAM150A | GPBAR1 | ENSP00000351345 | ENSP00000430886 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids | 0.751 |
| FAM150A | LTK | ENSP00000351345 | ENSP00000263800 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Leukocyte tyrosine kinase receptor; Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport | 0.775 |
| FAM150A | PCDHAC1 | ENSP00000351345 | ENSP00000253807 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.587 |
| FAM150A | SECISBP2 | ENSP00000351345 | ENSP00000364965 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.647 |
| FAM150A | ZNF540 | ENSP00000351345 | ENSP00000466274 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type | 0.630 |
| FAM150A | ZNF671 | ENSP00000351345 | ENSP00000321848 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Zinc finger protein 671; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.559 |
| FAM78A | FAM150A | ENSP00000361345 | ENSP00000351345 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.591 |
| FAM78A | PCDHAC1 | ENSP00000361345 | ENSP00000253807 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.669 |
| FAM78A | ZNF540 | ENSP00000361345 | ENSP00000466274 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type | 0.670 |
