TXNDC15 protein (human) - STRING database

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TXNDC15

Thioredoxin domain containing 15 (360 aa)

Predicted Functional Partners:

KRTCAP2

0.607

MRPS18A

0.602

MARCH6

0.549

TSTA3

0.527

PIGN

0.527

CAMLG

0.522

IGSF9B

0.512

DDX46

0.511

CHCHD7

0.481

CEP70

0.480

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAMLG	TXNDC15	ENSP00000297156	ENSP00000351157	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B	Thioredoxin domain containing 15	0.522
CEP70	TXNDC15	ENSP00000264982	ENSP00000351157	Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle	Thioredoxin domain containing 15	0.480
CHCHD7	TXNDC15	ENSP00000306425	ENSP00000351157	Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family	Thioredoxin domain containing 15	0.481
DDX46	TXNDC15	ENSP00000416534	ENSP00000351157	Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily	Thioredoxin domain containing 15	0.511
IGSF9B	MRPS18A	ENSP00000436552	ENSP00000361206	Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion; Fibronectin type III domain containing	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	0.426
IGSF9B	TXNDC15	ENSP00000436552	ENSP00000351157	Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion; Fibronectin type III domain containing	Thioredoxin domain containing 15	0.512
KRTCAP2	TXNDC15	ENSP00000295682	ENSP00000351157	Keratinocyte-associated protein 2; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate- specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid- beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1; Belong [...]	Thioredoxin domain containing 15	0.607
MARCH6	TXNDC15	ENSP00000274140	ENSP00000351157	E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers	Thioredoxin domain containing 15	0.549
MRPS18A	IGSF9B	ENSP00000361206	ENSP00000436552	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion; Fibronectin type III domain containing	0.426
MRPS18A	TSTA3	ENSP00000361206	ENSP00000398803	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogenase/reductase superfamily	0.442
MRPS18A	TXNDC15	ENSP00000361206	ENSP00000351157	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	Thioredoxin domain containing 15	0.602
PIGN	TXNDC15	ENSP00000350263	ENSP00000351157	GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation; Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily	Thioredoxin domain containing 15	0.527
TSTA3	MRPS18A	ENSP00000398803	ENSP00000361206	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogenase/reductase superfamily	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	0.442
TSTA3	TXNDC15	ENSP00000398803	ENSP00000351157	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogenase/reductase superfamily	Thioredoxin domain containing 15	0.527
TXNDC15	CAMLG	ENSP00000351157	ENSP00000297156	Thioredoxin domain containing 15	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B	0.522
TXNDC15	CEP70	ENSP00000351157	ENSP00000264982	Thioredoxin domain containing 15	Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle	0.480
TXNDC15	CHCHD7	ENSP00000351157	ENSP00000306425	Thioredoxin domain containing 15	Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family	0.481
TXNDC15	DDX46	ENSP00000351157	ENSP00000416534	Thioredoxin domain containing 15	Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily	0.511
TXNDC15	IGSF9B	ENSP00000351157	ENSP00000436552	Thioredoxin domain containing 15	Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion; Fibronectin type III domain containing	0.512
TXNDC15	KRTCAP2	ENSP00000351157	ENSP00000295682	Thioredoxin domain containing 15	Keratinocyte-associated protein 2; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate- specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid- beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1; Belong [...]	0.607

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