TMEM261 protein (human) - STRING database

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TMEM261

Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I (112 aa)

Predicted Functional Partners:

ARHGEF38

0.692

RIC1

0.678

ERMP1

0.648

UHRF2

0.630

ARMC7

0.620

KLHDC4

0.609

NEURL1

0.603

NDUFA8

0.562

PURG

0.558

TMEM41B

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF38	TMEM261	ENSP00000416125	ENSP00000350961	Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.692
ARMC7	KLHDC4	ENSP00000245543	ENSP00000270583	Armadillo repeat containing 7	Kelch domain containing 4	0.603
ARMC7	TMEM261	ENSP00000245543	ENSP00000350961	Armadillo repeat containing 7	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.620
ARMC7	TMEM41B	ENSP00000245543	ENSP00000433126	Armadillo repeat containing 7	Transmembrane protein 41B; Required for normal motor neuron development	0.531
ERMP1	RIC1	ENSP00000340427	ENSP00000416696	Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	0.603
ERMP1	TMEM261	ENSP00000340427	ENSP00000350961	Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.648
ERMP1	UHRF2	ENSP00000340427	ENSP00000276893	Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures	E3 ubiquitin-protein ligase UHRF2; E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131; PHD finger proteins	0.460
KLHDC4	ARMC7	ENSP00000270583	ENSP00000245543	Kelch domain containing 4	Armadillo repeat containing 7	0.603
KLHDC4	TMEM261	ENSP00000270583	ENSP00000350961	Kelch domain containing 4	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.609
KLHDC4	TMEM41B	ENSP00000270583	ENSP00000433126	Kelch domain containing 4	Transmembrane protein 41B; Required for normal motor neuron development	0.536
NDUFA8	TMEM261	ENSP00000362873	ENSP00000350961	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; NADH-ubiquinone oxidoreductase supernumerary subunits	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.562
NEURL1	TMEM261	ENSP00000358795	ENSP00000350961	E3 ubiquitin-protein ligase NEURL1; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; [...]	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.603
PURG	RIC1	ENSP00000418721	ENSP00000416696	Purine-rich element-binding protein gamma; Purine rich element binding protein G	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	0.424
PURG	TMEM261	ENSP00000418721	ENSP00000350961	Purine-rich element-binding protein gamma; Purine rich element binding protein G	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.558
RIC1	ERMP1	ENSP00000416696	ENSP00000340427	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures	0.603
RIC1	PURG	ENSP00000416696	ENSP00000418721	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	Purine-rich element-binding protein gamma; Purine rich element binding protein G	0.424
RIC1	TMEM261	ENSP00000416696	ENSP00000350961	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.678
RIC1	UHRF2	ENSP00000416696	ENSP00000276893	RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing	E3 ubiquitin-protein ligase UHRF2; E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131; PHD finger proteins	0.503
TMEM261	ARHGEF38	ENSP00000350961	ENSP00000416125	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing	0.692
TMEM261	ARMC7	ENSP00000350961	ENSP00000245543	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	Armadillo repeat containing 7	0.620

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