WDR37 protein (human) - STRING database

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WDR37

WD repeat-containing protein 37; WD repeat domain containing (494 aa)

Predicted Functional Partners:

PACS2

0.904

PACS1

0.888

TMEM60

0.827

WDR47

0.756

WDR63

0.748

WDR48

0.729

WDR72

0.728

AAMP

0.691

ARMC8

0.677

WDR36

0.677

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAMP	WDR36	ENSP00000248450	ENSP00000423067	Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing	WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex	0.684
AAMP	WDR37	ENSP00000248450	ENSP00000350954	Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing	WD repeat-containing protein 37; WD repeat domain containing	0.691
ARMC8	WDR37	ENSP00000420333	ENSP00000350954	Armadillo repeat containing 8	WD repeat-containing protein 37; WD repeat domain containing	0.677
PACS1	WDR37	ENSP00000316454	ENSP00000350954	Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN; Belongs to the PACS family	WD repeat-containing protein 37; WD repeat domain containing	0.888
PACS2	WDR37	ENSP00000393559	ENSP00000350954	Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct [...]	WD repeat-containing protein 37; WD repeat domain containing	0.904
TMEM60	WDR37	ENSP00000257663	ENSP00000350954	Transmembrane protein 60	WD repeat-containing protein 37; WD repeat domain containing	0.827
TMEM60	WDR72	ENSP00000257663	ENSP00000379619	Transmembrane protein 60	WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing	0.730
WDR36	AAMP	ENSP00000423067	ENSP00000248450	WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex	Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing	0.684
WDR36	WDR37	ENSP00000423067	ENSP00000350954	WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex	WD repeat-containing protein 37; WD repeat domain containing	0.677
WDR37	AAMP	ENSP00000350954	ENSP00000248450	WD repeat-containing protein 37; WD repeat domain containing	Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing	0.691
WDR37	ARMC8	ENSP00000350954	ENSP00000420333	WD repeat-containing protein 37; WD repeat domain containing	Armadillo repeat containing 8	0.677
WDR37	PACS1	ENSP00000350954	ENSP00000316454	WD repeat-containing protein 37; WD repeat domain containing	Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN; Belongs to the PACS family	0.888
WDR37	PACS2	ENSP00000350954	ENSP00000393559	WD repeat-containing protein 37; WD repeat domain containing	Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct [...]	0.904
WDR37	TMEM60	ENSP00000350954	ENSP00000257663	WD repeat-containing protein 37; WD repeat domain containing	Transmembrane protein 60	0.827
WDR37	WDR36	ENSP00000350954	ENSP00000423067	WD repeat-containing protein 37; WD repeat domain containing	WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex	0.677
WDR37	WDR47	ENSP00000350954	ENSP00000383599	WD repeat-containing protein 37; WD repeat domain containing	WD repeat-containing protein 47; WD repeat domain containing	0.756
WDR37	WDR48	ENSP00000350954	ENSP00000307491	WD repeat-containing protein 37; WD repeat domain containing	WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In complex with USP12, acts [...]	0.729
WDR37	WDR63	ENSP00000350954	ENSP00000294664	WD repeat-containing protein 37; WD repeat domain containing	WD repeat-containing protein 63; WD repeat domain containing	0.748
WDR37	WDR72	ENSP00000350954	ENSP00000379619	WD repeat-containing protein 37; WD repeat domain containing	WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing	0.728
WDR47	WDR37	ENSP00000383599	ENSP00000350954	WD repeat-containing protein 47; WD repeat domain containing	WD repeat-containing protein 37; WD repeat domain containing	0.756

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