node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | GAD1 | ENSP00000379845 | ENSP00000350928 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.981 |
ABAT | GAD2 | ENSP00000379845 | ENSP00000365437 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.982 |
ABAT | GLUD2 | ENSP00000379845 | ENSP00000327589 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family | 0.636 |
ABAT | GLUL | ENSP00000379845 | ENSP00000307900 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.961 |
GAD1 | ABAT | ENSP00000350928 | ENSP00000379845 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.981 |
GAD1 | GAD2 | ENSP00000350928 | ENSP00000365437 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.956 |
GAD1 | GLS | ENSP00000350928 | ENSP00000317379 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutaminase kidney isoform, mitochondrial; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity; Ankyrin repeat domain containing | 0.938 |
GAD1 | GLS2 | ENSP00000350928 | ENSP00000310447 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Ankyrin repeat domain containing | 0.941 |
GAD1 | GLUD2 | ENSP00000350928 | ENSP00000327589 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family | 0.929 |
GAD1 | GLUL | ENSP00000350928 | ENSP00000307900 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.948 |
GAD1 | RAB3A | ENSP00000350928 | ENSP00000222256 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases | 0.945 |
GAD1 | SLC32A1 | ENSP00000350928 | ENSP00000217420 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.999 |
GAD1 | SNAP25 | ENSP00000350928 | ENSP00000254976 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.959 |
GAD1 | SYT1 | ENSP00000350928 | ENSP00000261205 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.949 |
GAD2 | ABAT | ENSP00000365437 | ENSP00000379845 | Glutamate decarboxylase 2; Catalyzes the production of GABA | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.982 |
GAD2 | GAD1 | ENSP00000365437 | ENSP00000350928 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.956 |
GAD2 | GLS | ENSP00000365437 | ENSP00000317379 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutaminase kidney isoform, mitochondrial; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity; Ankyrin repeat domain containing | 0.934 |
GAD2 | GLS2 | ENSP00000365437 | ENSP00000310447 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Ankyrin repeat domain containing | 0.937 |
GAD2 | GLUD2 | ENSP00000365437 | ENSP00000327589 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family | 0.927 |
GAD2 | GLUL | ENSP00000365437 | ENSP00000307900 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.949 |