node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOE | TMCC2 | ENSP00000252486 | ENSP00000350718 | Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues; Apolipoproteins | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.713 |
ARFGAP3 | NAT9 | ENSP00000263245 | ENSP00000350467 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | 0.641 |
ARFGAP3 | PRPF38A | ENSP00000263245 | ENSP00000257181 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.680 |
ARFGAP3 | RBM15B | ENSP00000263245 | ENSP00000454545 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Putative RNA-binding protein 15B; May function in the regulation of alternative or illicit splicing; Belongs to the RRM Spen family | 0.618 |
ARFGAP3 | TMCC2 | ENSP00000263245 | ENSP00000350718 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.691 |
ASAP2 | NAT9 | ENSP00000281419 | ENSP00000350467 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | 0.545 |
ASAP2 | PRPF38A | ENSP00000281419 | ENSP00000257181 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.572 |
ASAP2 | RBM15B | ENSP00000281419 | ENSP00000454545 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Putative RNA-binding protein 15B; May function in the regulation of alternative or illicit splicing; Belongs to the RRM Spen family | 0.528 |
ASAP2 | TMCC2 | ENSP00000281419 | ENSP00000350718 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.562 |
CCDC167 | TMCC2 | ENSP00000362507 | ENSP00000350718 | Coiled-coil domain containing 167 | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.573 |
DSTYK | TMCC2 | ENSP00000356130 | ENSP00000350718 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.742 |
NAA16 | TMCC2 | ENSP00000368716 | ENSP00000350718 | N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity; Armadillo-like helical domain containing | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.645 |
NAT9 | ARFGAP3 | ENSP00000350467 | ENSP00000263245 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.641 |
NAT9 | ASAP2 | ENSP00000350467 | ENSP00000281419 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | 0.545 |
NAT9 | PRPF38A | ENSP00000350467 | ENSP00000257181 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | 0.675 |
NAT9 | RBM15B | ENSP00000350467 | ENSP00000454545 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | Putative RNA-binding protein 15B; May function in the regulation of alternative or illicit splicing; Belongs to the RRM Spen family | 0.572 |
NAT9 | TMCC2 | ENSP00000350467 | ENSP00000350718 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing | 0.680 |
PRPF38A | ARFGAP3 | ENSP00000257181 | ENSP00000263245 | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.680 |
PRPF38A | ASAP2 | ENSP00000257181 | ENSP00000281419 | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | 0.572 |
PRPF38A | NAT9 | ENSP00000257181 | ENSP00000350467 | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | 0.675 |