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  • 11.0 [archived version]
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WDR66 WDR66 CCDC167 CCDC167 NAA16 NAA16 ASAP2 ASAP2 TMCC2 TMCC2 PRPF38A PRPF38A DSTYK DSTYK NAT9 NAT9 RBM15B RBM15B ARFGAP3 ARFGAP3 APOE APOE
"TMCC2" - Transmembrane and coiled-coil domains protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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TMCC2Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing (709 aa)    
Predicted Functional Partners:
DSTYK
Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (929 aa)
     
   
  0.742
PRPF38A
Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family (312 aa)
           
  0.721
APOE
Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues; Apolipoproteins (317 aa)
       
 
  0.713
ARFGAP3
ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs (516 aa)
           
  0.691
RBM15B
Putative RNA-binding protein 15B; May function in the regulation of alternative or illicit splicing; Belongs to the RRM Spen family (890 aa)
           
  0.687
NAT9
GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily (207 aa)
           
  0.680
WDR66
Cilia- and flagella-associated protein 251; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; WD repeat domain containing (1149 aa)
           
  0.649
NAA16
N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity; Armadillo-like helical domain containing (864 aa)
           
  0.645
CCDC167
Coiled-coil domain containing 167 (97 aa)
           
  0.573
ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing (1006 aa)
           
  0.562
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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