| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DTX2 | RFX4 | ENSP00000322885 | ENSP00000350552 | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.538 |
| DTX2 | RFXANK | ENSP00000322885 | ENSP00000305071 | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family | DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity); Ankyrin repeat domain containing | 0.653 |
| ESR1 | RFX4 | ENSP00000405330 | ENSP00000350552 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.583 |
| FOXJ1 | PIFO | ENSP00000323880 | ENSP00000358753 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner | 0.405 |
| FOXJ1 | RFX4 | ENSP00000323880 | ENSP00000350552 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.619 |
| FOXJ1 | TTC25 | ENSP00000323880 | ENSP00000478589 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility; Tetratricopeptide repeat domain containing | 0.590 |
| GPR56 | RFX4 | ENSP00000455215 | ENSP00000350552 | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell- cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoi [...] | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.561 |
| GSX2 | RFX4 | ENSP00000319118 | ENSP00000350552 | GS homeobox 2; During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5’-CNAATTAG-3’ DNA sequence; HOXL subclass homeoboxes | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.656 |
| MFSD2B | RFX4 | ENSP00000385527 | ENSP00000350552 | Major facilitator superfamily domain-containing protein 2B; Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity) | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.536 |
| PIFO | FOXJ1 | ENSP00000358753 | ENSP00000323880 | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | 0.405 |
| PIFO | RFX4 | ENSP00000358753 | ENSP00000350552 | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | 0.608 |
| RFX4 | DTX2 | ENSP00000350552 | ENSP00000322885 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Belongs to the Deltex family | 0.538 |
| RFX4 | ESR1 | ENSP00000350552 | ENSP00000405330 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.583 |
| RFX4 | FOXJ1 | ENSP00000350552 | ENSP00000323880 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | 0.619 |
| RFX4 | GPR56 | ENSP00000350552 | ENSP00000455215 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell- cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoi [...] | 0.561 |
| RFX4 | GSX2 | ENSP00000350552 | ENSP00000319118 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | GS homeobox 2; During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5’-CNAATTAG-3’ DNA sequence; HOXL subclass homeoboxes | 0.656 |
| RFX4 | MFSD2B | ENSP00000350552 | ENSP00000385527 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Major facilitator superfamily domain-containing protein 2B; Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity) | 0.536 |
| RFX4 | PIFO | ENSP00000350552 | ENSP00000358753 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner | 0.608 |
| RFX4 | RFXANK | ENSP00000350552 | ENSP00000305071 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity); Ankyrin repeat domain containing | 0.583 |
| RFX4 | TMEM138 | ENSP00000350552 | ENSP00000278826 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family | Transmembrane protein 138; Required for ciliogenesis | 0.582 |
