NAT9 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NAT9

GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily (207 aa)

Predicted Functional Partners:

TSTD2

0.737

PLEC

0.724

NAA20

0.708

EEF1E1

0.694

NAT14

0.688

C1QTNF2

0.686

TMCC2

0.680

NAT10

0.679

PRPF38A

0.675

KRT5

0.670

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QTNF2	NAT9	ENSP00000377545	ENSP00000350467	Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.686
EEF1E1	NAT9	ENSP00000369038	ENSP00000350467	Eukaryotic translation elongation factor 1 epsilon-1; Positive modulator of ATM response to DNA damage	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.694
KRT5	NAT9	ENSP00000252242	ENSP00000350467	Keratin, type II cytoskeletal 5; Keratins, type II	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.670
KRT5	PLEC	ENSP00000252242	ENSP00000323856	Keratin, type II cytoskeletal 5; Keratins, type II	Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity; Plakins	0.668
NAA20	NAT10	ENSP00000335636	ENSP00000257829	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	0.498
NAA20	NAT14	ENSP00000335636	ENSP00000205194	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	0.623
NAA20	NAT9	ENSP00000335636	ENSP00000350467	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.708
NAT10	NAA20	ENSP00000257829	ENSP00000335636	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	0.498
NAT10	NAT14	ENSP00000257829	ENSP00000205194	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	0.600
NAT10	NAT9	ENSP00000257829	ENSP00000350467	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.679
NAT14	NAA20	ENSP00000205194	ENSP00000335636	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	0.623
NAT14	NAT10	ENSP00000205194	ENSP00000257829	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	0.600
NAT14	NAT9	ENSP00000205194	ENSP00000350467	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	0.688
NAT9	C1QTNF2	ENSP00000350467	ENSP00000377545	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2	0.686
NAT9	EEF1E1	ENSP00000350467	ENSP00000369038	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	Eukaryotic translation elongation factor 1 epsilon-1; Positive modulator of ATM response to DNA damage	0.694
NAT9	KRT5	ENSP00000350467	ENSP00000252242	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	Keratin, type II cytoskeletal 5; Keratins, type II	0.670
NAT9	NAA20	ENSP00000350467	ENSP00000335636	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily	0.708
NAT9	NAT10	ENSP00000350467	ENSP00000257829	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Can acetylate both histones and microtubules. Histone acetyla [...]	0.679
NAT9	NAT14	ENSP00000350467	ENSP00000205194	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases	0.688
NAT9	PLEC	ENSP00000350467	ENSP00000323856	GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily	Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity; Plakins	0.724

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About