node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETFB | METTL20 | ENSP00000346173 | ENSP00000350353 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.955 |
FAM86A | METTL10 | ENSP00000398502 | ENSP00000357829 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | 0.875 |
FAM86A | METTL12 | ENSP00000398502 | ENSP00000431287 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.500 |
FAM86A | METTL18 | ENSP00000398502 | ENSP00000307975 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase | 0.791 |
FAM86A | METTL20 | ENSP00000398502 | ENSP00000350353 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.792 |
FAM86A | METTL21A | ENSP00000398502 | ENSP00000415115 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates ’Lys-561’ in HSPA1, ’Lys- 564’ in HSPA2, ’Lys-585’ in HSPA5, ’Lys-563’ in HSPA6 and ’Lys- 561’ in HSPA8 | 0.818 |
FAM86A | METTL21C | ENSP00000398502 | ENSP00000267273 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Protein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase; Belongs to the methyltransferase superfamily. METTL21 family | 0.804 |
FAM86A | VCPKMT | ENSP00000398502 | ENSP00000379201 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | Protein-lysine methyltransferase METTL21D; Protein-lysine N-methyltransferase that specifically trimethylates ’Lys-315’ of VCP/p97; this modification may decrease VCP ATPase activity; Belongs to the methyltransferase superfamily. METTL21 family | 0.804 |
METTL10 | FAM86A | ENSP00000357829 | ENSP00000398502 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | 0.875 |
METTL10 | METTL12 | ENSP00000357829 | ENSP00000431287 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | 0.802 |
METTL10 | METTL18 | ENSP00000357829 | ENSP00000307975 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase | 0.767 |
METTL10 | METTL20 | ENSP00000357829 | ENSP00000350353 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain | 0.811 |
METTL10 | METTL21A | ENSP00000357829 | ENSP00000415115 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates ’Lys-561’ in HSPA1, ’Lys- 564’ in HSPA2, ’Lys-585’ in HSPA5, ’Lys-563’ in HSPA6 and ’Lys- 561’ in HSPA8 | 0.770 |
METTL10 | METTL21C | ENSP00000357829 | ENSP00000267273 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase; Belongs to the methyltransferase superfamily. METTL21 family | 0.725 |
METTL10 | MTRF1L | ENSP00000357829 | ENSP00000356202 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Peptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG | 0.566 |
METTL10 | NDUFAF7 | ENSP00000357829 | ENSP00000002125 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein arginine methyltransferase NDUFAF7, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of ’Arg-118’ of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex; Belongs to the NDUFAF7 family | 0.782 |
METTL10 | VCPKMT | ENSP00000357829 | ENSP00000379201 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | Protein-lysine methyltransferase METTL21D; Protein-lysine N-methyltransferase that specifically trimethylates ’Lys-315’ of VCP/p97; this modification may decrease VCP ATPase activity; Belongs to the methyltransferase superfamily. METTL21 family | 0.811 |
METTL12 | FAM86A | ENSP00000431287 | ENSP00000398502 | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ | 0.500 |
METTL12 | METTL10 | ENSP00000431287 | ENSP00000357829 | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at ’Lys-318’ | 0.802 |
METTL12 | METTL18 | ENSP00000431287 | ENSP00000307975 | Methyltransferase-like protein 12, mitochondrial; Putative methyltransferase | Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase | 0.552 |