node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGN | COL11A1 | ENSP00000327336 | ENSP00000359114 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | 0.538 |
BGN | COL1A1 | ENSP00000327336 | ENSP00000225964 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Collagens | 0.873 |
BGN | COL2A1 | ENSP00000327336 | ENSP00000369889 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces | 0.684 |
BGN | COL4A2 | ENSP00000327336 | ENSP00000353654 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.710 |
BGN | COL6A1 | ENSP00000327336 | ENSP00000355180 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family | 0.742 |
BGN | COL9A1 | ENSP00000327336 | ENSP00000349790 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.927 |
BGN | COL9A2 | ENSP00000327336 | ENSP00000361834 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.925 |
BGN | COL9A3 | ENSP00000327336 | ENSP00000341640 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.925 |
BGN | MMP13 | ENSP00000327336 | ENSP00000260302 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.566 |
COL11A1 | BGN | ENSP00000359114 | ENSP00000327336 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | 0.538 |
COL11A1 | COL11A2 | ENSP00000359114 | ENSP00000363840 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | 0.907 |
COL11A1 | COL1A1 | ENSP00000359114 | ENSP00000225964 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Collagens | 0.935 |
COL11A1 | COL2A1 | ENSP00000359114 | ENSP00000369889 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces | 0.935 |
COL11A1 | COL4A2 | ENSP00000359114 | ENSP00000353654 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.935 |
COL11A1 | COL6A1 | ENSP00000359114 | ENSP00000355180 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family | 0.939 |
COL11A1 | COL9A1 | ENSP00000359114 | ENSP00000349790 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.931 |
COL11A1 | COL9A2 | ENSP00000359114 | ENSP00000361834 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.936 |
COL11A1 | COL9A3 | ENSP00000359114 | ENSP00000341640 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.937 |
COL11A1 | MMP13 | ENSP00000359114 | ENSP00000260302 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.479 |
COL11A2 | COL11A1 | ENSP00000363840 | ENSP00000359114 | Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens | 0.907 |