| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCK | DCTD | ENSP00000286648 | ENSP00000349576 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | 0.980 |
| DCK | DCTPP1 | ENSP00000286648 | ENSP00000322524 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism | 0.926 |
| DCK | DTYMK | ENSP00000286648 | ENSP00000304802 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.680 |
| DCK | DUT | ENSP00000286648 | ENSP00000370376 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family | 0.721 |
| DCK | NT5C2 | ENSP00000286648 | ENSP00000339479 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | 0.968 |
| DCK | NT5C3A | ENSP00000286648 | ENSP00000484415 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.943 |
| DCK | NT5E | ENSP00000286648 | ENSP00000257770 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | 5’-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities; Belongs to the 5’-nucleotidase family | 0.920 |
| DCK | TK1 | ENSP00000286648 | ENSP00000301634 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.878 |
| DCK | TYMS | ENSP00000286648 | ENSP00000315644 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.782 |
| DCTD | DCK | ENSP00000349576 | ENSP00000286648 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | 0.980 |
| DCTD | DCTPP1 | ENSP00000349576 | ENSP00000322524 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism | 0.965 |
| DCTD | DTYMK | ENSP00000349576 | ENSP00000304802 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.976 |
| DCTD | DUT | ENSP00000349576 | ENSP00000370376 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family | 0.978 |
| DCTD | NT5C2 | ENSP00000349576 | ENSP00000339479 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | 0.954 |
| DCTD | NT5C3A | ENSP00000349576 | ENSP00000484415 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.942 |
| DCTD | NT5E | ENSP00000349576 | ENSP00000257770 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | 5’-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities; Belongs to the 5’-nucleotidase family | 0.923 |
| DCTD | TK1 | ENSP00000349576 | ENSP00000301634 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.967 |
| DCTD | TK2 | ENSP00000349576 | ENSP00000299697 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | 0.931 |
| DCTD | TYMS | ENSP00000349576 | ENSP00000315644 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.993 |
| DCTPP1 | DCK | ENSP00000322524 | ENSP00000286648 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | 0.926 |
