| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf115 | TMEM71 | ENSP00000294889 | ENSP00000349296 | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115 | Transmembrane protein 71; Belongs to the TMEM71 family | 0.510 |
| CCRN4L | TMEM71 | ENSP00000280614 | ENSP00000349296 | Nocturnin; Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteoge [...] | Transmembrane protein 71; Belongs to the TMEM71 family | 0.504 |
| DCSTAMP | RIMS2 | ENSP00000297581 | ENSP00000262231 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing | 0.446 |
| DCSTAMP | TMEM71 | ENSP00000297581 | ENSP00000349296 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | Transmembrane protein 71; Belongs to the TMEM71 family | 0.572 |
| DPYS | TMEM71 | ENSP00000276651 | ENSP00000349296 | Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate | Transmembrane protein 71; Belongs to the TMEM71 family | 0.495 |
| FAM228A | RFX8 | ENSP00000295150 | ENSP00000401536 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.646 |
| FAM228A | TMEM71 | ENSP00000295150 | ENSP00000349296 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Transmembrane protein 71; Belongs to the TMEM71 family | 0.645 |
| FAM83B | RC3H2 | ENSP00000304078 | ENSP00000362774 | Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.475 |
| FAM83B | TMEM71 | ENSP00000304078 | ENSP00000349296 | Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades | Transmembrane protein 71; Belongs to the TMEM71 family | 0.486 |
| RC3H2 | FAM83B | ENSP00000362774 | ENSP00000304078 | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades | 0.475 |
| RC3H2 | TMEM71 | ENSP00000362774 | ENSP00000349296 | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | Transmembrane protein 71; Belongs to the TMEM71 family | 0.506 |
| RFX8 | FAM228A | ENSP00000401536 | ENSP00000295150 | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | 0.646 |
| RFX8 | TMEM71 | ENSP00000401536 | ENSP00000349296 | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | Transmembrane protein 71; Belongs to the TMEM71 family | 0.527 |
| RIMS2 | DCSTAMP | ENSP00000262231 | ENSP00000297581 | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | 0.446 |
| RIMS2 | TMEM71 | ENSP00000262231 | ENSP00000349296 | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing | Transmembrane protein 71; Belongs to the TMEM71 family | 0.645 |
| TMEM151A | TMEM71 | ENSP00000326244 | ENSP00000349296 | Transmembrane protein 151A | Transmembrane protein 71; Belongs to the TMEM71 family | 0.621 |
| TMEM71 | C1orf115 | ENSP00000349296 | ENSP00000294889 | Transmembrane protein 71; Belongs to the TMEM71 family | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115 | 0.510 |
| TMEM71 | CCRN4L | ENSP00000349296 | ENSP00000280614 | Transmembrane protein 71; Belongs to the TMEM71 family | Nocturnin; Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteoge [...] | 0.504 |
| TMEM71 | DCSTAMP | ENSP00000349296 | ENSP00000297581 | Transmembrane protein 71; Belongs to the TMEM71 family | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | 0.572 |
| TMEM71 | DPYS | ENSP00000349296 | ENSP00000276651 | Transmembrane protein 71; Belongs to the TMEM71 family | Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate | 0.495 |
