| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARID3A | DIRAS1 | ENSP00000263620 | ENSP00000325836 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | 0.493 |
| ARID3A | GRIN3B | ENSP00000263620 | ENSP00000234389 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.589 |
| ARID3A | LPPR3 | ENSP00000263620 | ENSP00000352962 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | Lipid phosphate phosphatase-related protein type 3 | 0.664 |
| ARID3A | MED16 | ENSP00000263620 | ENSP00000325612 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.640 |
| ARID3A | TMEM259 | ENSP00000263620 | ENSP00000349087 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress; Belongs to the membralin family | 0.675 |
| ARID3A | WDR18 | ENSP00000263620 | ENSP00000476117 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | WD repeat-containing protein 18; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit; Belongs to the WD repeat IPI3/WDR18 family | 0.596 |
| DIRAS1 | ARID3A | ENSP00000325836 | ENSP00000263620 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-rich interaction domain containing | 0.493 |
| DIRAS1 | GADD45B | ENSP00000325836 | ENSP00000215631 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | 0.425 |
| DIRAS1 | GRIN3B | ENSP00000325836 | ENSP00000234389 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.598 |
| DIRAS1 | LPPR3 | ENSP00000325836 | ENSP00000352962 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | Lipid phosphate phosphatase-related protein type 3 | 0.655 |
| DIRAS1 | MED16 | ENSP00000325836 | ENSP00000325612 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.635 |
| DIRAS1 | TMEM259 | ENSP00000325836 | ENSP00000349087 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress; Belongs to the membralin family | 0.654 |
| DIRAS1 | WDR18 | ENSP00000325836 | ENSP00000476117 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | WD repeat-containing protein 18; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit; Belongs to the WD repeat IPI3/WDR18 family | 0.494 |
| ERLIN2 | TMEM259 | ENSP00000276461 | ENSP00000349087 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress; Belongs to the membralin family | 0.770 |
| ERLIN2 | UBAC2 | ENSP00000276461 | ENSP00000383911 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family | 0.898 |
| GADD45B | DIRAS1 | ENSP00000215631 | ENSP00000325836 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family | 0.425 |
| GADD45B | GRIN3B | ENSP00000215631 | ENSP00000234389 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.548 |
| GADD45B | LPPR3 | ENSP00000215631 | ENSP00000352962 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | Lipid phosphate phosphatase-related protein type 3 | 0.575 |
| GADD45B | MED16 | ENSP00000215631 | ENSP00000325612 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.514 |
| GADD45B | TMEM259 | ENSP00000215631 | ENSP00000349087 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress; Belongs to the membralin family | 0.583 |
