• Version:
  • 11.0 [archived version]
STRINGSTRING
PMEL PMEL CTAG1B CTAG1B CTAG2 CTAG2 BAGE5 BAGE5 CTAG1A CTAG1A GAGE2A GAGE2A MAGEA1 MAGEA1 GAGE1 GAGE1 DDX43 DDX43 GAGE12F GAGE12F CSAG1 CSAG1
"MAGEA1" - Melanoma-associated antigen 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAGEA1Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family (309 aa)    
Predicted Functional Partners:
BAGE5
B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family (39 aa)
            
  0.905
GAGE2A
G antigen 2A (116 aa)
      
   
  0.902
GAGE12F
G antigen 12F; Belongs to the GAGE family (117 aa)
      
   
  0.889
CTAG1A
Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family (180 aa)
      
   
  0.865
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family (180 aa)
      
   
  0.865
GAGE1
G antigen 1; Belongs to the GAGE family (117 aa)
      
   
  0.840
PMEL
Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity (668 aa)
      
   
  0.759
CTAG2
Cancer/testis antigen 2 (210 aa)
      
   
  0.756
DDX43
Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 (648 aa)
            
  0.756
CSAG1
Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 (78 aa)
      
   
  0.750
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >