| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CELSR2 | MEGF6 | ENSP00000271332 | ENSP00000348982 | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.617 |
| DTX1 | MEGF6 | ENSP00000257600 | ENSP00000348982 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.639 |
| DTX1 | RITA1 | ENSP00000257600 | ENSP00000448680 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | 0.657 |
| FRMD4A | MEGF6 | ENSP00000350032 | ENSP00000348982 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.586 |
| FRMD4A | RITA1 | ENSP00000350032 | ENSP00000448680 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | 0.601 |
| GULP1 | MEGF6 | ENSP00000386289 | ENSP00000348982 | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.655 |
| MEGF6 | CELSR2 | ENSP00000348982 | ENSP00000271332 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.617 |
| MEGF6 | DTX1 | ENSP00000348982 | ENSP00000257600 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | 0.639 |
| MEGF6 | FRMD4A | ENSP00000348982 | ENSP00000350032 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | 0.586 |
| MEGF6 | GULP1 | ENSP00000348982 | ENSP00000386289 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | 0.655 |
| MEGF6 | RITA1 | ENSP00000348982 | ENSP00000448680 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | 0.752 |
| MEGF6 | SDF4 | ENSP00000348982 | ENSP00000353094 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family | 0.645 |
| MEGF6 | USP17L11 | ENSP00000348982 | ENSP00000400880 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 11; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.565 |
| MEGF6 | USP17L18 | ENSP00000348982 | ENSP00000423503 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 18; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection | 0.565 |
| MEGF6 | WRAP73 | ENSP00000348982 | ENSP00000270708 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | WD repeat-containing protein WRAP73; The SSX2IP-WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97-CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | 0.801 |
| MEGF6 | ZBTB40 | ENSP00000348982 | ENSP00000384527 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation; BTB domain containing | 0.749 |
| RITA1 | DTX1 | ENSP00000448680 | ENSP00000257600 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | 0.657 |
| RITA1 | FRMD4A | ENSP00000448680 | ENSP00000350032 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | 0.601 |
| RITA1 | MEGF6 | ENSP00000448680 | ENSP00000348982 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.752 |
| SDF4 | MEGF6 | ENSP00000353094 | ENSP00000348982 | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.645 |
