node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMMECR1 | CCDC25 | ENSP00000262844 | ENSP00000348933 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.629 |
AMMECR1 | NEMF | ENSP00000262844 | ENSP00000298310 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex. May indirectly play a role in nuclear export | 0.415 |
AMMECR1L | CCDC25 | ENSP00000272647 | ENSP00000348933 | AMMECR1-like protein; AMMECR1 like | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.539 |
C1QBP | CCDC25 | ENSP00000225698 | ENSP00000348933 | Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex [...] | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.543 |
C1QBP | SLC25A11 | ENSP00000225698 | ENSP00000225665 | Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex [...] | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity); Solute carriers | 0.546 |
CCDC25 | AMMECR1 | ENSP00000348933 | ENSP00000262844 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.629 |
CCDC25 | AMMECR1L | ENSP00000348933 | ENSP00000272647 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | AMMECR1-like protein; AMMECR1 like | 0.539 |
CCDC25 | C1QBP | ENSP00000348933 | ENSP00000225698 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex [...] | 0.543 |
CCDC25 | NEMF | ENSP00000348933 | ENSP00000298310 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex. May indirectly play a role in nuclear export | 0.541 |
CCDC25 | NUDT16L1 | ENSP00000348933 | ENSP00000306670 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at ’Lys-20’ (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain an [...] | 0.499 |
CCDC25 | RCC2 | ENSP00000348933 | ENSP00000364585 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | 0.546 |
CCDC25 | RNASEH2A | ENSP00000348933 | ENSP00000221486 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes; Belongs to the RNase HII family. Eukaryotic subfamily | 0.620 |
CCDC25 | SH2D4A | ENSP00000348933 | ENSP00000265807 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function; Protein phosphatase 1 regulatory subunits | 0.562 |
CCDC25 | SLC25A11 | ENSP00000348933 | ENSP00000225665 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity); Solute carriers | 0.533 |
CCDC25 | SRD5A3 | ENSP00000348933 | ENSP00000264228 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) | 0.546 |
NEMF | AMMECR1 | ENSP00000298310 | ENSP00000262844 | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex. May indirectly play a role in nuclear export | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.415 |
NEMF | CCDC25 | ENSP00000298310 | ENSP00000348933 | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex. May indirectly play a role in nuclear export | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.541 |
NUDT16L1 | CCDC25 | ENSP00000306670 | ENSP00000348933 | Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at ’Lys-20’ (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain an [...] | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.499 |
RCC2 | CCDC25 | ENSP00000364585 | ENSP00000348933 | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | Coiled-coil domain containing 25; Belongs to the CCDC25 family | 0.546 |
RCC2 | SRD5A3 | ENSP00000364585 | ENSP00000264228 | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) | 0.531 |