node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM33 | CDH11 | ENSP00000348912 | ENSP00000268603 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.587 |
ADAM33 | DPP10 | ENSP00000348912 | ENSP00000376855 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | 0.733 |
ADAM33 | HRSP12 | ENSP00000348912 | ENSP00000254878 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | 2-iminobutanoate/2-iminopropanoate deaminase; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5’-phosphate-dependent dehydratases including L-threonine dehydratase | 0.553 |
ADAM33 | IL4R | ENSP00000348912 | ENSP00000379111 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 | 0.549 |
ADAM33 | MS4A2 | ENSP00000348912 | ENSP00000278888 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family | 0.577 |
ADAM33 | NPSR1 | ENSP00000348912 | ENSP00000370950 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases | 0.689 |
ADAM33 | ORMDL3 | ENSP00000348912 | ENSP00000377724 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling; Belongs to the ORM family | 0.668 |
ADAM33 | PACSIN2 | ENSP00000348912 | ENSP00000263246 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Protein kinase C and casein kinase substrate in neurons protein 2; Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis; Belongs to the PACSIN family | 0.561 |
ADAM33 | PHF11 | ENSP00000348912 | ENSP00000367570 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression; PHD finger proteins | 0.738 |
ADAM33 | VEGFA | ENSP00000348912 | ENSP00000478570 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed fo [...] | 0.611 |
CDH11 | ADAM33 | ENSP00000268603 | ENSP00000348912 | Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | 0.587 |
CDH11 | PACSIN2 | ENSP00000268603 | ENSP00000263246 | Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | Protein kinase C and casein kinase substrate in neurons protein 2; Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis; Belongs to the PACSIN family | 0.408 |
DPP10 | ADAM33 | ENSP00000376855 | ENSP00000348912 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | 0.733 |
DPP10 | MS4A2 | ENSP00000376855 | ENSP00000278888 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family | 0.418 |
DPP10 | NPSR1 | ENSP00000376855 | ENSP00000370950 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases | 0.687 |
DPP10 | ORMDL3 | ENSP00000376855 | ENSP00000377724 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling; Belongs to the ORM family | 0.579 |
DPP10 | PHF11 | ENSP00000376855 | ENSP00000367570 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression; PHD finger proteins | 0.797 |
HRSP12 | ADAM33 | ENSP00000254878 | ENSP00000348912 | 2-iminobutanoate/2-iminopropanoate deaminase; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5’-phosphate-dependent dehydratases including L-threonine dehydratase | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | 0.553 |
IL4R | ADAM33 | ENSP00000379111 | ENSP00000348912 | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing | 0.549 |
IL4R | MS4A2 | ENSP00000379111 | ENSP00000278888 | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family | 0.511 |