node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH5 | METAP1 | ENSP00000296412 | ENSP00000296411 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.518 |
ADH5 | N4BP2 | ENSP00000296412 | ENSP00000261435 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.560 |
ADH5 | VPS13B | ENSP00000296412 | ENSP00000351346 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family | 0.430 |
ADH5 | ZNF770 | ENSP00000296412 | ENSP00000348673 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.565 |
CYP4V2 | N4BP2 | ENSP00000368079 | ENSP00000261435 | Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21 [...] | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.503 |
CYP4V2 | VPS13B | ENSP00000368079 | ENSP00000351346 | Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21 [...] | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family | 0.407 |
CYP4V2 | ZNF770 | ENSP00000368079 | ENSP00000348673 | Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21 [...] | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.567 |
LRRC2 | NUPL1 | ENSP00000379241 | ENSP00000371155 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Belongs to the NUP58 family | 0.474 |
LRRC2 | NUS1 | ENSP00000379241 | ENSP00000357480 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Dehydrodolichyl diphosphate synthase complex subunit NUS1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...] | 0.511 |
LRRC2 | ZNF770 | ENSP00000379241 | ENSP00000348673 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.673 |
METAP1 | ADH5 | ENSP00000296411 | ENSP00000296412 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | 0.518 |
METAP1 | N4BP2 | ENSP00000296411 | ENSP00000261435 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | 0.665 |
METAP1 | VPS13B | ENSP00000296411 | ENSP00000351346 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family | 0.557 |
METAP1 | ZNF770 | ENSP00000296411 | ENSP00000348673 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.719 |
N4BP2 | ADH5 | ENSP00000261435 | ENSP00000296412 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | 0.560 |
N4BP2 | CYP4V2 | ENSP00000261435 | ENSP00000368079 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21 [...] | 0.503 |
N4BP2 | METAP1 | ENSP00000261435 | ENSP00000296411 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.665 |
N4BP2 | VPS13B | ENSP00000261435 | ENSP00000351346 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family | 0.647 |
N4BP2 | ZNF770 | ENSP00000261435 | ENSP00000348673 | NEDD4-binding protein 2; Has 5’-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.743 |
NUPL1 | LRRC2 | ENSP00000371155 | ENSP00000379241 | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Belongs to the NUP58 family | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.474 |