| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM32 | TMPRSS11F | ENSP00000369238 | ENSP00000348639 | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Transmembrane protease serine 11F; Probable serine protease | 0.424 |
| ASGR1 | SPRTN | ENSP00000269299 | ENSP00000295050 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | 0.521 |
| ASGR1 | TMPRSS11F | ENSP00000269299 | ENSP00000348639 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | Transmembrane protease serine 11F; Probable serine protease | 0.482 |
| CLEC10A | SPRTN | ENSP00000254868 | ENSP00000295050 | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | 0.521 |
| CLEC10A | TMPRSS11F | ENSP00000254868 | ENSP00000348639 | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | Transmembrane protease serine 11F; Probable serine protease | 0.482 |
| DNAH14 | TMPRSS11F | ENSP00000383737 | ENSP00000348639 | Dynein axonemal heavy chain 14 | Transmembrane protease serine 11F; Probable serine protease | 0.448 |
| DNAJB14 | TMPRSS11F | ENSP00000404381 | ENSP00000348639 | DnaJ homolog subfamily B member 14; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70’s ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70- together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nas [...] | Transmembrane protease serine 11F; Probable serine protease | 0.428 |
| SPRTN | ASGR1 | ENSP00000295050 | ENSP00000269299 | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | 0.521 |
| SPRTN | CLEC10A | ENSP00000295050 | ENSP00000254868 | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | 0.521 |
| SPRTN | TMPRSS11F | ENSP00000295050 | ENSP00000348639 | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | Transmembrane protease serine 11F; Probable serine protease | 0.656 |
| TMPRSS11F | ADAM32 | ENSP00000348639 | ENSP00000369238 | Transmembrane protease serine 11F; Probable serine protease | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.424 |
| TMPRSS11F | ASGR1 | ENSP00000348639 | ENSP00000269299 | Transmembrane protease serine 11F; Probable serine protease | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface; C-type lectin domain containing | 0.482 |
| TMPRSS11F | CLEC10A | ENSP00000348639 | ENSP00000254868 | Transmembrane protease serine 11F; Probable serine protease | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing | 0.482 |
| TMPRSS11F | DNAH14 | ENSP00000348639 | ENSP00000383737 | Transmembrane protease serine 11F; Probable serine protease | Dynein axonemal heavy chain 14 | 0.448 |
| TMPRSS11F | DNAJB14 | ENSP00000348639 | ENSP00000404381 | Transmembrane protease serine 11F; Probable serine protease | DnaJ homolog subfamily B member 14; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70’s ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70- together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nas [...] | 0.428 |
| TMPRSS11F | SPRTN | ENSP00000348639 | ENSP00000295050 | Transmembrane protease serine 11F; Probable serine protease | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response- acts as a ’reader’ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | 0.656 |
| TMPRSS11F | TSPYL1 | ENSP00000348639 | ENSP00000357597 | Transmembrane protease serine 11F; Probable serine protease | Testis-specific Y-encoded-like protein 1; TSPY like 1 | 0.400 |
| TSPYL1 | TMPRSS11F | ENSP00000357597 | ENSP00000348639 | Testis-specific Y-encoded-like protein 1; TSPY like 1 | Transmembrane protease serine 11F; Probable serine protease | 0.400 |
