node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP15 | BTG4 | ENSP00000252677 | ENSP00000348300 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | 0.794 |
BMP15 | MOS | ENSP00000252677 | ENSP00000310722 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | MOS proto-oncogene, serine/threonine kinase | 0.810 |
BMP15 | WEE2 | ENSP00000252677 | ENSP00000380675 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at ’Tyr-15’, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at ’Tyr-15’, to ensure exit from meiosis in oocytes and promote pronuclear formation ( [...] | 0.517 |
BMP15 | ZAR1 | ENSP00000252677 | ENSP00000329803 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type | 0.767 |
BMP15 | ZAR1L | ENSP00000252677 | ENSP00000437289 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | ZAR1-like protein; Zinc fingers 3CxxC-type; Belongs to the ZAR1 family | 0.402 |
BTG4 | BMP15 | ENSP00000348300 | ENSP00000252677 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | 0.794 |
BTG4 | CNOT7 | ENSP00000348300 | ENSP00000355279 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | 0.863 |
BTG4 | CNOT8 | ENSP00000348300 | ENSP00000430493 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | 0.755 |
BTG4 | MARK3 | ENSP00000348300 | ENSP00000411397 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on ’Ser-216’. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 | 0.543 |
BTG4 | MOS | ENSP00000348300 | ENSP00000310722 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | MOS proto-oncogene, serine/threonine kinase | 0.602 |
BTG4 | MSH4 | ENSP00000348300 | ENSP00000263187 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair MutS family | 0.572 |
BTG4 | NANOG | ENSP00000348300 | ENSP00000229307 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT] [...] | 0.637 |
BTG4 | WEE2 | ENSP00000348300 | ENSP00000380675 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at ’Tyr-15’, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at ’Tyr-15’, to ensure exit from meiosis in oocytes and promote pronuclear formation ( [...] | 0.645 |
BTG4 | ZAR1 | ENSP00000348300 | ENSP00000329803 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type | 0.587 |
BTG4 | ZAR1L | ENSP00000348300 | ENSP00000437289 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | ZAR1-like protein; Zinc fingers 3CxxC-type; Belongs to the ZAR1 family | 0.879 |
CNOT7 | BTG4 | ENSP00000355279 | ENSP00000348300 | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | 0.863 |
CNOT7 | CNOT8 | ENSP00000355279 | ENSP00000430493 | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | 0.907 |
CNOT8 | BTG4 | ENSP00000430493 | ENSP00000348300 | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | 0.755 |
CNOT8 | CNOT7 | ENSP00000430493 | ENSP00000355279 | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | 0.907 |
MARK3 | BTG4 | ENSP00000411397 | ENSP00000348300 | MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on ’Ser-216’. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family | 0.543 |