node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4GALNT4 | C1QTNF4 | ENSP00000328277 | ENSP00000302274 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | 0.756 |
B4GALNT4 | MXRA7 | ENSP00000328277 | ENSP00000348050 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.673 |
C1QTNF4 | B4GALNT4 | ENSP00000302274 | ENSP00000328277 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | 0.756 |
C1QTNF4 | MXRA7 | ENSP00000302274 | ENSP00000348050 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q and TNF related | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.573 |
ENSG00000267168 | MXRA7 | ENSP00000466829 | ENSP00000348050 | Uncharacterized protein | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.581 |
ENSG00000267168 | PRPSAP1 | ENSP00000466829 | ENSP00000414624 | Uncharacterized protein | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.426 |
ENSG00000267168 | PRPSAP2 | ENSP00000466829 | ENSP00000268835 | Uncharacterized protein | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.426 |
ENSG00000267168 | ST6GALNAC2 | ENSP00000466829 | ENSP00000225276 | Uncharacterized protein | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Sialyltransferases | 0.536 |
JMJD6 | METTL23 | ENSP00000394085 | ENSP00000482599 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | Methyltransferase-like protein 23; Probable methyltransferase | 0.570 |
JMJD6 | MXRA7 | ENSP00000394085 | ENSP00000348050 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.528 |
JMJD6 | PRPSAP1 | ENSP00000394085 | ENSP00000414624 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.506 |
JMJD6 | PRPSAP2 | ENSP00000394085 | ENSP00000268835 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.458 |
JMJD6 | ST6GALNAC2 | ENSP00000394085 | ENSP00000225276 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Sialyltransferases | 0.408 |
METTL23 | JMJD6 | ENSP00000482599 | ENSP00000394085 | Methyltransferase-like protein 23; Probable methyltransferase | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an argi [...] | 0.570 |
METTL23 | MXRA7 | ENSP00000482599 | ENSP00000348050 | Methyltransferase-like protein 23; Probable methyltransferase | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.801 |
METTL23 | PRPSAP1 | ENSP00000482599 | ENSP00000414624 | Methyltransferase-like protein 23; Probable methyltransferase | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.642 |
METTL23 | PRPSAP2 | ENSP00000482599 | ENSP00000268835 | Methyltransferase-like protein 23; Probable methyltransferase | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.426 |
METTL23 | RHBDF2 | ENSP00000482599 | ENSP00000322775 | Methyltransferase-like protein 23; Probable methyltransferase | Inactive rhomboid protein 2; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity); Belongs to the peptidase S54 family | 0.502 |
METTL23 | ST6GALNAC2 | ENSP00000482599 | ENSP00000225276 | Methyltransferase-like protein 23; Probable methyltransferase | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Sialyltransferases | 0.536 |
MXRA7 | B4GALNT4 | ENSP00000348050 | ENSP00000328277 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | 0.673 |