| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADRM1 | DDI1 | ENSP00000478877 | ENSP00000302805 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | Protein DDI1 homolog 1; Probable aspartic protease | 0.883 |
| ADRM1 | PSMD4 | ENSP00000478877 | ENSP00000357879 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 0.999 |
| ADRM1 | UBA52 | ENSP00000478877 | ENSP00000388107 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] | 0.960 |
| ADRM1 | UBQLN3 | ENSP00000478877 | ENSP00000347997 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | Ubiquilin-3; Ubiquilin family | 0.715 |
| CCNA1 | PSMD4 | ENSP00000255465 | ENSP00000357879 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 0.901 |
| CCNA1 | UBA52 | ENSP00000255465 | ENSP00000388107 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] | 0.900 |
| CCNA1 | UBQLN3 | ENSP00000255465 | ENSP00000347997 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily | Ubiquilin-3; Ubiquilin family | 0.737 |
| DDI1 | ADRM1 | ENSP00000302805 | ENSP00000478877 | Protein DDI1 homolog 1; Probable aspartic protease | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | 0.883 |
| DDI1 | PSMD4 | ENSP00000302805 | ENSP00000357879 | Protein DDI1 homolog 1; Probable aspartic protease | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 0.872 |
| DDI1 | UBQLN3 | ENSP00000302805 | ENSP00000347997 | Protein DDI1 homolog 1; Probable aspartic protease | Ubiquilin-3; Ubiquilin family | 0.672 |
| FAM71F1 | GTSF1L | ENSP00000326652 | ENSP00000362094 | Protein FAM71F1; Family with sequence similarity 71 member F1 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like | 0.702 |
| FAM71F1 | TMEM225 | ENSP00000326652 | ENSP00000364166 | Protein FAM71F1; Family with sequence similarity 71 member F1 | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC | 0.744 |
| FAM71F1 | UBQLN3 | ENSP00000326652 | ENSP00000347997 | Protein FAM71F1; Family with sequence similarity 71 member F1 | Ubiquilin-3; Ubiquilin family | 0.659 |
| FAM71F1 | WBSCR28 | ENSP00000326652 | ENSP00000316775 | Protein FAM71F1; Family with sequence similarity 71 member F1 | Transmembrane protein 270; Williams-Beuren syndrome chromosome region 28 | 0.723 |
| GTSF1L | FAM71F1 | ENSP00000362094 | ENSP00000326652 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like | Protein FAM71F1; Family with sequence similarity 71 member F1 | 0.702 |
| GTSF1L | TMEM225 | ENSP00000362094 | ENSP00000364166 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC | 0.788 |
| GTSF1L | UBQLN3 | ENSP00000362094 | ENSP00000347997 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like | Ubiquilin-3; Ubiquilin family | 0.677 |
| GTSF1L | WBSCR28 | ENSP00000362094 | ENSP00000316775 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like | Transmembrane protein 270; Williams-Beuren syndrome chromosome region 28 | 0.731 |
| LONRF2 | UBA52 | ENSP00000377086 | ENSP00000388107 | LON peptidase N-terminal domain and ring finger 2 | Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] | 0.760 |
| LONRF2 | UBQLN3 | ENSP00000377086 | ENSP00000347997 | LON peptidase N-terminal domain and ring finger 2 | Ubiquilin-3; Ubiquilin family | 0.728 |
