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STRINGSTRING
CKAP2 CKAP2 LRRC45 LRRC45 CCDC137 CCDC137 GGA1 GGA1 NEK5 NEK5 ANO4 ANO4 CCDC65 CCDC65 FN3K FN3K CSRNP2 CSRNP2 TRIM36 TRIM36 ACOT12 ACOT12
"NEK5" - Serine/threonine-protein kinase Nek5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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NEK5Serine/threonine-protein kinase Nek5; NIMA related kinase 5; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily (708 aa)    
Predicted Functional Partners:
FN3K
Fructosamine-3-kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme (309 aa)
            
  0.626
TRIM36
E3 ubiquitin-protein ligase TRIM36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization; Belongs to the TRIM/RBCC family (728 aa)
            
  0.620
CKAP2
Cytoskeleton-associated protein 2; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity) (683 aa)
            
  0.603
CCDC65
Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family (484 aa)
      
   
  0.598
CSRNP2
Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits (543 aa)
            
  0.587
ACOT12
Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases (555 aa)
      
   
  0.562
LRRC45
Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion (670 aa)
            
  0.550
CCDC137
Coiled-coil domain containing 137 (289 aa)
            
  0.516
ANO4
Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity; Belongs to the anoctamin family (955 aa)
      
   
  0.515
GGA1
ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (639 aa)
            
  0.513
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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