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STRINGSTRING
TMBIM1 TMBIM1 FAM178B FAM178B NKX1-2 NKX1-2 WNT3A WNT3A APCDD1 APCDD1 AXIN2 AXIN2 ZCCHC24 ZCCHC24 LRP5 LRP5 MMD2 MMD2 ASPSCR1 ASPSCR1 LRP11 LRP11
"APCDD1" - Protein APCDD1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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APCDD1Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis; Belongs to the APCDD1 family (514 aa)    
Predicted Functional Partners:
MMD2
Monocyte to macrophage differentiation associated 2; Progestin and adipoQ receptor family (270 aa)
      
   
  0.632
ASPSCR1
Tether containing UBX domain for GLUT4; Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT; UBX domain containing (647 aa)
            
  0.613
LRP5
Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] (1615 aa)
        
 
  0.570
ZCCHC24
Zinc finger CCHC-type containing 24; Zinc fingers 3CxxC-type (241 aa)
      
   
  0.551
WNT3A
Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube; Endogenous ligands (352 aa)
        
 
  0.525
NKX1-2
NK1 transcription factor-related protein 2; May function in cell specification, particularly in the CNS; NKL subclass homeoboxes and pseudogenes (310 aa)
            
  0.508
FAM178B
Protein FAM178B; Family with sequence similarity 178 member B (679 aa)
            
  0.473
TMBIM1
Protein lifeguard 3; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling; Transmembrane BAX inhibitor motif containing (311 aa)
            
  0.442
LRP11
Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family (500 aa)
            
  0.436
AXIN2
Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) (843 aa)
      
   
  0.413
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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