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STRINGSTRING
TAS2R38 TAS2R38 CEP170 CEP170 XK XK EDN2 EDN2 XKRX XKRX EDN3 EDN3 KEL KEL PIP PIP RHD RHD RHCE RHCE XKR3 XKR3
"KEL" - Kell blood group glycoprotein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
KELKell blood group glycoprotein; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3; Blood group antigens (732 aa)    
Predicted Functional Partners:
XK
Membrane transport protein XK; May be involved in sodium-dependent transport of neutral amino acids or oligopeptides; Blood group antigens (444 aa)
      
  0.989
EDN3
Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands (238 aa)
        
  0.973
XKR3
XK-related protein 3; XK related family; Belongs to the XK family (459 aa)
      
   
  0.804
XKRX
XK-related protein 2; XK related, X-linked (449 aa)
            
  0.800
RHCE
Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Blood group antigens (417 aa)
      
   
  0.757
PIP
Prolactin induced protein; Belongs to the PIP family (146 aa)
            
  0.757
CEP170
Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family (1584 aa)
            
  0.613
RHD
Rh blood group D antigen; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily (493 aa)
      
   
  0.604
EDN2
Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands (178 aa)
        
 
  0.599
TAS2R38
Taste receptor type 2 member 38; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity); Taste 2 receptors (333 aa)
            
  0.597
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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